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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   SEPTEMBER 2013 , Volume 16 , Number 9; Page(s) 955 To 961.
 
Paper: 

MATERNAL VOLUNTARY EXERCISE DURING PREGNANCY ENHANCES THE SPATIAL LEARNING ACQUISITION BUT NOT THE RETENTION OF MEMORY IN RAT PUPS VIA A TRKB-MEDIATED MECHANISM: THE ROLE OF HIPPOCAMPAL BDNF EXPRESSION

 
 
Author(s):  M. AKHAVAN MAZIAR, MILADI GORJI HOSSEIN*, EMAMI ABARGHOIE MITRA, SAFARI MANOUCHEHR, SADIGHI MOGHADDAM BIZHAN, VAFAEI ABBAS A., RASHIDY POUR ALI
 
* RESEARCH CENTER AND DEPARTMENT OF PHYSIOLOGY, SCHOOL OF MEDICINE, SEMNAN UNIVERSITY OF MEDICAL SCIENCES, SEMNAN, IRAN
 
Abstract: 

Objective(s): The effect of maternal voluntary exercise on hippocampal BDNF level in rat offspring was studied. In addition, the possible role of hippocampal BDNF receptors in maternal exercise induced enhancement of learning in the rat pups was investigated.
Materials and Methods: Pregnant rats have been randomly assigned to sedentary control or voluntary exercise groups. Each of the exercising pregnant rats was given access to a cage that was equipped with a running wheel until the end of their pregnancy. On post natal day (PND) 36, two groups consisted of 7 male rat pups in each group from sedentary or exercised mothers were sacrificed and the hippocampus was dissected for BDNF proteins level determination. Also, bilateral injection of K252a to the hippocampus was used to block the hippocampal BDNF action on PND59 in the rat pups.
Results: Voluntary exercise during pregnancy significantly increased the level of BDNF protein in the hippocampus of the rat pups on PND36 compared to the control group (P=0.048). Inhibiting BDNF action abolished the exercise-induced improvement of learning acquisition in offspring in training trials (P=0.0001). No difference was observed in the platform location latency and the time spent in the target in the probe test between two groups.
Conclusion: This study demonstrates that voluntary exercise during pregnancy via a TrkB-mediated mechanism enhances the spatial learning acquisition, however, not the retention of memory in the rat pups.

 
Keyword(s): BDNF, HIPPOCAMPUS, K252A, MEMORY, TRKB, OFFSPRING, VOLUNTARY EXERCISE
 
 
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Click to Cite.
APA: Copy

M. AKHAVAN, M., & MILADI GORJI, H., & EMAMI ABARGHOIE, M., & SAFARI, M., & SADIGHI MOGHADDAM, B., & VAFAEI, A., & RASHIDY POUR, A. (2013). MATERNAL VOLUNTARY EXERCISE DURING PREGNANCY ENHANCES THE SPATIAL LEARNING ACQUISITION BUT NOT THE RETENTION OF MEMORY IN RAT PUPS VIA A TRKB-MEDIATED MECHANISM: THE ROLE OF HIPPOCAMPAL BDNF EXPRESSION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(9), 955-961. https://www.sid.ir/en/journal/ViewPaper.aspx?id=405374



Vancouver: Copy

M. AKHAVAN MAZIAR, MILADI GORJI HOSSEIN, EMAMI ABARGHOIE MITRA, SAFARI MANOUCHEHR, SADIGHI MOGHADDAM BIZHAN, VAFAEI ABBAS A., RASHIDY POUR ALI. MATERNAL VOLUNTARY EXERCISE DURING PREGNANCY ENHANCES THE SPATIAL LEARNING ACQUISITION BUT NOT THE RETENTION OF MEMORY IN RAT PUPS VIA A TRKB-MEDIATED MECHANISM: THE ROLE OF HIPPOCAMPAL BDNF EXPRESSION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2013 [cited 2021May06];16(9):955-961. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405374



IEEE: Copy

M. AKHAVAN, M., MILADI GORJI, H., EMAMI ABARGHOIE, M., SAFARI, M., SADIGHI MOGHADDAM, B., VAFAEI, A., RASHIDY POUR, A., 2013. MATERNAL VOLUNTARY EXERCISE DURING PREGNANCY ENHANCES THE SPATIAL LEARNING ACQUISITION BUT NOT THE RETENTION OF MEMORY IN RAT PUPS VIA A TRKB-MEDIATED MECHANISM: THE ROLE OF HIPPOCAMPAL BDNF EXPRESSION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 16(9), pp.955-961. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405374.



 
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