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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   JULY 2014 , Volume 17 , Number 7; Page(s) 502 To 508.
 
Paper: 

N-PHENYL-2-P-TOLYLTHIAZOLE-4-CARBOXAMIDE DERIVATIVES: SYN-THESIS AND CYTOTOXICITY EVALUATION AS ANTICANCER AGENTS

 
 
Author(s):  MOHAMMADI FARANI AHMAD, FOROUMADI ALIREZA, REZVANI KASHANI MONIREH, ALIABADI ALIREZA*
 
* FACULTY OF PHARMACY, KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES, KERMANSHAH, IRAN
 
Abstract: 

Objective (s): According to the prevalence of neoplastic diseases, there is a deep necessity for discovery of novel anticancer drugs in the field of medicinal chemistry. In the current study, a new series of phenylthiazole derivatives (compounds 4a-4f) was synthesized and their anticancer activity was assessed in vitro.
Materials and Methods: All synthesized derivatives were evaluated towards three human cancerous cell lines of SKNMC (Neuroblastoma), Hep-G2 (Human hepatocarcinoma) and MCF-7 cell (Breast cancer) using MTT assay and obtained values (IC50±SD) were compared with doxorubicin.
Results: Unfortunately, none of the synthesized compounds showed superior activity than doxorubicin against cancerous cell lines. MCF-7 cell line was the most resistant cell line against tested compounds. Compounds 4c with para nitro (IC50=10.8±0.08
mM) and 4d with meta chlorine (IC50=11.6±0.12 mM) moieties exerted the highest cytotoxic effects towards SKNMC and Hep-G2 cell lines respectively.
Conclusion: A new series of phenylthiazole derivatives were synthesized and their anticancer activity was assessed against cancerous cell lines. More structural modifications and derivatization is necessary to achieve to the more potent compounds.

 
Keyword(s): ANTICANCER, CYTOTOXICITY, SYNTHESIS, THIAZOLE
 
 
References: 
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Click to Cite.
APA: Copy

MOHAMMADI FARANI, A., & FOROUMADI, A., & REZVANI KASHANI, M., & ALIABADI, A. (2014). N-PHENYL-2-P-TOLYLTHIAZOLE-4-CARBOXAMIDE DERIVATIVES: SYN-THESIS AND CYTOTOXICITY EVALUATION AS ANTICANCER AGENTS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(7), 502-508. https://www.sid.ir/en/journal/ViewPaper.aspx?id=405373



Vancouver: Copy

MOHAMMADI FARANI AHMAD, FOROUMADI ALIREZA, REZVANI KASHANI MONIREH, ALIABADI ALIREZA. N-PHENYL-2-P-TOLYLTHIAZOLE-4-CARBOXAMIDE DERIVATIVES: SYN-THESIS AND CYTOTOXICITY EVALUATION AS ANTICANCER AGENTS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2014 [cited 2021May10];17(7):502-508. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405373



IEEE: Copy

MOHAMMADI FARANI, A., FOROUMADI, A., REZVANI KASHANI, M., ALIABADI, A., 2014. N-PHENYL-2-P-TOLYLTHIAZOLE-4-CARBOXAMIDE DERIVATIVES: SYN-THESIS AND CYTOTOXICITY EVALUATION AS ANTICANCER AGENTS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 17(7), pp.502-508. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405373.



 
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