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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   AUGUST 2013 , Volume 16 , Number 8; Page(s) 901 To 905.
 
Paper: 

USING EGGSHELL MEMBRANE AS NERVE GUIDE CHANNELS IN PERIPHERAL NERVE REGENERATION

 
 
Author(s):  FARJAH GHOLAM HOSSEIN*, HESHMATIAN BEHNAM, KARIMIPOUR MOJTABA, SABERI ALI
 
* DEPARTMENT OF ANATOMY, FACULTY OF MEDICINE, URMIA UNIVERSITY OF MEDICAL SCIENCES, URMIA, IRAN
 
Abstract: 

Objective(s): The aim of this study was to evaluate the final outcome of nerve regeneration across the eggsell membrane (ESM) tube conduit in comparison with autograft.
Materials and Methods: Thirty adult male rats (250-300 g) were randomized into (1) ESM conduit, (2) autograft, and (3) sham surgery groups. The eggs submerged in 5% acetic acid. The decalcifying membranes were cut into four pieces, rotated over the teflon mandrel and dried at 37°C. The left sciatic nerve was surgically cut. A 10-mm nerve segment was cut and removed. In the ESM group, the proximal and distal cut ends of the sciatic nerve were telescoped into the nerve guides. In the autograft group, the 10 mm nerve segment was reversed and used as an autologous nerve graft. All animals were evaluated by sciatic functional index (SFI) and electrophysiology testing.
Results: The improvement in SFI from the first to the last evalution in ESM and autograft groups were evaluated. On days 49 and 60 post-operation, the mean SFI of ESM group was significantly greater than the autograft group (P<0.05). On day 90, the mean nerve conduction velocity (NCV) of ESM group was greater than autograft group, although the difference was not statistically significant (P>0.05).
Conclusion: These findings demonstrate that ESM effectively enhances nerve regeneration and promotes functional recovery in injured sciatic nerve of rat.

 
Keyword(s): EGGSHELL MEMBRANE, NERVE REGENERATION, RAT, SCIATIC NERVE
 
 
References: 
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Click to Cite.
APA: Copy

FARJAH, G., & HESHMATIAN, B., & KARIMIPOUR, M., & SABERI, A. (2013). USING EGGSHELL MEMBRANE AS NERVE GUIDE CHANNELS IN PERIPHERAL NERVE REGENERATION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 16(8), 901-905. https://www.sid.ir/en/journal/ViewPaper.aspx?id=405371



Vancouver: Copy

FARJAH GHOLAM HOSSEIN, HESHMATIAN BEHNAM, KARIMIPOUR MOJTABA, SABERI ALI. USING EGGSHELL MEMBRANE AS NERVE GUIDE CHANNELS IN PERIPHERAL NERVE REGENERATION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2013 [cited 2021May13];16(8):901-905. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405371



IEEE: Copy

FARJAH, G., HESHMATIAN, B., KARIMIPOUR, M., SABERI, A., 2013. USING EGGSHELL MEMBRANE AS NERVE GUIDE CHANNELS IN PERIPHERAL NERVE REGENERATION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 16(8), pp.901-905. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405371.



 
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