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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   JULY 2014 , Volume 17 , Number 7; Page(s) 483 To 489.
 
Paper: 

HISTOCHEMICAL STUDY OF RETINAL PHOTORECEPTORS DEVELOPMENT DURING PRE- AND POSTNATAL PERIOD AND THEIR ASSOCIATION WITH RETINAL PIGMENT EPITHELIUM

 
 
Author(s):  EBRAHIMI VAHID, VOJOUDI ELHAM, FAZEL ALIREZA, EBRAHIMZADEH BIDESKAN ALIREZA*
 
* DEPARTMENT OF ANATOMY AND CELL BIOLOGY, SCHOOL OF MEDICINE, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, AZADI SQ., VAKILABAD BLVD., MASHHAD, IRAN
 
Abstract: 

Objective (s): The aim of this study was to evaluate distribution and changes of glycoconjugates of retinal photoreceptors during both pre- and postnatal development.
Materials and Methods: Tissue sections from days 15 to 20 of Wistar rat embryos and 1 to 12 postnatal days of rat newborns including developing eye were prepared for lectinhistochemistry technique. Horseradish peroxidase (HRP) -labeled lectins including Vicia villosa (VVA), peanut agglutinin (PNA), Maclura pomifera (MPA) and wheat germ agglutinin (WGA-??) were used. Alcian blue (pH 2.5) was used for counterstaining.
Results: Interphotoreceptor matrix (IPM) plays a crucial role in photoreceptors differentiation and acts as a mediator in interactions between photoreceptors and retinal pigment epithelium (RPE). Specific cell surface glycoconjugates secreted from cone cells could help us to distinguish these cells from rod photoreceptors. Our results for the first time revealed the strong reaction of cone photoreceptors with the cone-specific lectin (PNA) at postnatal day 12 (P12). Postnatal day 12 can be determined as the final differentiation of cone photoreceptors.
Conclusion: According to our findings, we suggest that the generation of the eye photoreceptors begins from pre- natal period and their final differentiations will continue to postnatal period. Glycoconjugates including (
b-D-Gal [1–3] -D-GalNac) and (b-D-Gal) terminal sugars play a critical role in the pre- and postnatal development and differentiation of retinal photoreceptors.

 
Keyword(s): DEVELOPMENT, LECTIN HISTOCHEMISTRY, PHOTORECEPTORS, RETINA
 
 
References: 
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Click to Cite.
APA: Copy

EBRAHIMI, V., & VOJOUDI, E., & FAZEL, A., & EBRAHIMZADEH BIDESKAN, A. (2014). HISTOCHEMICAL STUDY OF RETINAL PHOTORECEPTORS DEVELOPMENT DURING PRE- AND POSTNATAL PERIOD AND THEIR ASSOCIATION WITH RETINAL PIGMENT EPITHELIUM. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 17(7), 483-489. https://www.sid.ir/en/journal/ViewPaper.aspx?id=405358



Vancouver: Copy

EBRAHIMI VAHID, VOJOUDI ELHAM, FAZEL ALIREZA, EBRAHIMZADEH BIDESKAN ALIREZA. HISTOCHEMICAL STUDY OF RETINAL PHOTORECEPTORS DEVELOPMENT DURING PRE- AND POSTNATAL PERIOD AND THEIR ASSOCIATION WITH RETINAL PIGMENT EPITHELIUM. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 2014 [cited 2021May15];17(7):483-489. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405358



IEEE: Copy

EBRAHIMI, V., VOJOUDI, E., FAZEL, A., EBRAHIMZADEH BIDESKAN, A., 2014. HISTOCHEMICAL STUDY OF RETINAL PHOTORECEPTORS DEVELOPMENT DURING PRE- AND POSTNATAL PERIOD AND THEIR ASSOCIATION WITH RETINAL PIGMENT EPITHELIUM. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, [online] 17(7), pp.483-489. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405358.



 
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