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Paper Information

Journal:   SCIENTIA IRANICA   2012 , Volume 19 , Number 6 (TRANSACTIONS C: CHEMISTRY AND CHEMICAL ENGINEERING); Page(s) 1580 To 1583.
 
Paper: 

CURCUMIN AND ITS DERIVATIVES: MODERATE INHIBITORS OF ACETYLCHOLINESTERASE, BUTYRYLCHOLINESTERASE AND TRYPSIN

 
 
Author(s):  ABBASI M.A.*, ILYAS M., AZIZ UR REHMAN -, SONIA A., SHAHWAR D., RAZA M.A., KHAN K.M., ASHRAF M., AFZAL I., AMBREEN N.
 
* DEPARTMENT OF CHEMISTRY, GOVERNMENT COLLEGE UNIVERSITY, LAHORE-54000, PAKISTAN
 
Abstract: 

Curcumin, a polyphenol yellow orange pigment present in Indian spice “turmeric”, is a member of the ginger family (Zingiberaceae). The extract of turmeric was obtained by using soxhlet apparatus at 45-55 oC, using methanol as solvent and then curcumin was isolated from methanolic extract by column chromatography. In the present study, a series of four new derivatives of curcumin (3a-d) were synthesized by reacting curcumin (1) with different alkyl halides (2a-d) using DMF and lithium hydride. The structures of natural curcumin and its synthetic derivatives were confirmed with the help of their 1H-NMR spectra and all these were screened against acetylcholinesterase, butyrylcholinesterase, lipoxygenase and trypsin enzymes. Curcumin and its derivatives exhibited moderate inhibitory potential against all aforesaid enzymes.

 
Keyword(s): CURCUMIN, SYNTHETIC DERIVATIVES, ACETYLCHOLINESTERASE, BUTYRYLCHOLINESTERASE, LIPOXYGENASE, TRYPSIN
 
 
References: 
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Click to Cite.
APA: Copy

ABBASI, M., & ILYAS, M., & AZIZ UR REHMAN, -., & SONIA, A., & SHAHWAR, D., & RAZA, M., & KHAN, K., & ASHRAF, M., & AFZAL, I., & AMBREEN, N. (2012). CURCUMIN AND ITS DERIVATIVES: MODERATE INHIBITORS OF ACETYLCHOLINESTERASE, BUTYRYLCHOLINESTERASE AND TRYPSIN. SCIENTIA IRANICA, 19(6 (TRANSACTIONS C: CHEMISTRY AND CHEMICAL ENGINEERING)), 1580-1583. https://www.sid.ir/en/journal/ViewPaper.aspx?id=405013



Vancouver: Copy

ABBASI M.A., ILYAS M., AZIZ UR REHMAN -, SONIA A., SHAHWAR D., RAZA M.A., KHAN K.M., ASHRAF M., AFZAL I., AMBREEN N.. CURCUMIN AND ITS DERIVATIVES: MODERATE INHIBITORS OF ACETYLCHOLINESTERASE, BUTYRYLCHOLINESTERASE AND TRYPSIN. SCIENTIA IRANICA. 2012 [cited 2021May13];19(6 (TRANSACTIONS C: CHEMISTRY AND CHEMICAL ENGINEERING)):1580-1583. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405013



IEEE: Copy

ABBASI, M., ILYAS, M., AZIZ UR REHMAN, -., SONIA, A., SHAHWAR, D., RAZA, M., KHAN, K., ASHRAF, M., AFZAL, I., AMBREEN, N., 2012. CURCUMIN AND ITS DERIVATIVES: MODERATE INHIBITORS OF ACETYLCHOLINESTERASE, BUTYRYLCHOLINESTERASE AND TRYPSIN. SCIENTIA IRANICA, [online] 19(6 (TRANSACTIONS C: CHEMISTRY AND CHEMICAL ENGINEERING)), pp.1580-1583. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=405013.



 
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