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Paper Information

Journal:   JOURNAL OF ANESTHESIOLOGY AND PAIN (PERSIAN)   FALL 2014 , Volume 5 , Number 1; Page(s) 29 To 35.
 
Paper: 

THE EFFECT OF PREMEDICATION WITH 300 MG PREGABALIN ON POSTOPERATIVE PAIN AND OPIOID CONSUMPTION IN PATIENTS UNDERGOING ELECTIVE ORTHOPEDIC SURGERY

 
 
Author(s):  NADERI NABI BAHRAM, HAGHIGHI MOHAMMAD*, SEDIGHINEJAD ABBAS, PALIZKAR MARYAM, FATHI AMIRHOSSEIN, POURREZA MARYAM, BEHZADNIA HAMID
 
* GUILAN UNIVERSITY OF MEDICAL SCIENCES, POURSINA HOSPITAL, ANESTHESIOLOGY RESEARCH CENTER, RASHT
 
Abstract: 

Aims and Background: Nowadays, multimodal approach is used to control post-operative pain. Pregabalin has been shown to have analgesic effects on postoperative pain as a Gaba-Amino-Buteric (GABA) analogue. This prospective, randomized, double-blind, controlled study has evaluated the beneficial effect of Pregabalin pretreatment on postoperative pain and opioid consumption in patints undergoing orthopedic elective surgery.
Materials and methods: Sixty ASA 1-2 patients, scheduled for orthopedic elective surgery under spinal anesthesia, were randomly divided into two groups. Group 1 received 300 mg Pregabalin one hour before the operation and Group 2 was given Placebo capsule. Patient-controlled intravenous analgesia (PCIA) device, prepared with Sufentanil, was connected to both groups for postoperative analgesia. Postoperative pain scores according to visual analogue scale (VAS), opioid consumption, and side-effects like nausea were recorded for 12 hours after surgery. P value<0.05 was considered significant.
Findings: According to visual analogue scale (VAS), pain scores were significantly lower in Pregabalin group at post anesthesia care unit (PACU), 6 hours and 12 hours post-operatively (p<0.05). Also pethidine consumption was significantly less than the placebo group in Pregabalin group (p<0.05).
Conclusions: Administering a single dose of 300 mg Pregabalin orally, and 1 hour before elective orthopedic surgery under spinal anesthesia, significantly reduces postoperative pain and opioid consumption.

 
Keyword(s): ORTHOPEDIC SURGERY, SPINAL ANESTHESIA, PREGABALIN, POST-OPERATIVE PAIN
 
References: 
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