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Journal:   JOURNAL OF ANESTHESIOLOGY AND PAIN (PERSIAN)   FALL 2014 , Volume 5 , Number 1; Page(s) 29 To 35.
 
Paper: 

The Effect Of Premedication With 300 Mg Pregabalin On Postoperative Pain And Opioid Consumption In Patients Undergoing Elective Orthopedic Surgery

 
 
Author(s):  Naderi Nabi Bahram, Haghighi Mohammad*, Sedighinejad Abbas, Palizkar Maryam, Fathi Amirhossein, Pourreza Maryam, Behzadnia Hamid
 
* GUILAN UNIVERSITY OF MEDICAL SCIENCES, POURSINA HOSPITAL, ANESTHESIOLOGY RESEARCH CENTER, RASHT
 
Abstract: 
Aims and Background: Nowadays, multimodal approach is used to control post-operative pain. Pregabalin has been shown to have analgesic effects on postoperative pain as a Gaba-Amino-Buteric (GABA) analogue. This prospective, randomized, double-blind, controlled study has evaluated the beneficial effect of Pregabalin pretreatment on postoperative pain and opioid consumption in patints undergoing orthopedic elective surgery.Materials and methods: Sixty ASA 1-2 patients, scheduled for orthopedic elective surgery under spinal anesthesia, were randomly divided into two groups. Group 1 received 300 mg Pregabalin one hour before the operation and Group 2 was given Placebo capsule. Patient-controlled intravenous analgesia (PCIA) device, prepared with Sufentanil, was connected to both groups for postoperative analgesia. Postoperative pain scores according to visual analogue scale (VAS), opioid consumption, and side-effects like nausea were recorded for 12 hours after surgery. P value<0.05 was considered significant.Findings: According to visual analogue scale (VAS), pain scores were significantly lower in Pregabalin group at post anesthesia care unit (PACU), 6 hours and 12 hours post-operatively (p<0.05). Also pethidine consumption was significantly less than the placebo group in Pregabalin group (p<0.05).Conclusions: Administering a single dose of 300 mg Pregabalin orally, and 1 hour before elective orthopedic surgery under spinal anesthesia, significantly reduces postoperative pain and opioid consumption.
 
Keyword(s): ORTHOPEDIC SURGERY, SPINAL ANESTHESIA, PREGABALIN, POST-OPERATIVE PAIN
 
 
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APA: Copy

NADERI NABI, B., & HAGHIGHI, M., & SEDIGHINEJAD, A., & PALIZKAR, M., & FATHI, A., & POURREZA, M., & BEHZADNIA, H. (2014). THE EFFECT OF PREMEDICATION WITH 300 MG PREGABALIN ON POSTOPERATIVE PAIN AND OPIOID CONSUMPTION IN PATIENTS UNDERGOING ELECTIVE ORTHOPEDIC SURGERY. JOURNAL OF ANESTHESIOLOGY AND PAIN (PERSIAN), 5(1), 29-35. https://www.sid.ir/en/journal/ViewPaper.aspx?id=404399



Vancouver: Copy

NADERI NABI BAHRAM, HAGHIGHI MOHAMMAD, SEDIGHINEJAD ABBAS, PALIZKAR MARYAM, FATHI AMIRHOSSEIN, POURREZA MARYAM, BEHZADNIA HAMID. THE EFFECT OF PREMEDICATION WITH 300 MG PREGABALIN ON POSTOPERATIVE PAIN AND OPIOID CONSUMPTION IN PATIENTS UNDERGOING ELECTIVE ORTHOPEDIC SURGERY. JOURNAL OF ANESTHESIOLOGY AND PAIN (PERSIAN). 2014 [cited 2022June30];5(1):29-35. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=404399



IEEE: Copy

NADERI NABI, B., HAGHIGHI, M., SEDIGHINEJAD, A., PALIZKAR, M., FATHI, A., POURREZA, M., BEHZADNIA, H., 2014. THE EFFECT OF PREMEDICATION WITH 300 MG PREGABALIN ON POSTOPERATIVE PAIN AND OPIOID CONSUMPTION IN PATIENTS UNDERGOING ELECTIVE ORTHOPEDIC SURGERY. JOURNAL OF ANESTHESIOLOGY AND PAIN (PERSIAN), [online] 5(1), pp.29-35. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=404399.



 
 
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