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Paper Information

Journal:   SCIENTIA IRANICA   2012 , Volume 19 , Number 3 (TRANSACTIONS C: CHEMISTRY AND CHEMICAL ENGINEERING); Page(s) 574 To 578.
 
Paper: 

GREEN PROCEDURE FOR THE SYNTHESIS OF BIS (INDOLYL) METHANES IN WATER (RESEARCH NOTE)

 
 
Author(s):  AZIZI N.*, GHOLIBEGHLO E., MANOCHERI Z.
 
* CHEMISTRY AND CHEMICAL ENGINEERING RESEARCH CENTER OF IRAN, TEHRAN, IRAN
 
Abstract: 

A green and environmentally benign protocol for squaric acid catalyst electrophilic substitution reactions of indole derivatives, with various aldehydes in water, in good to excellent yields, is developed. The advantages of low sensitivity towards moisture and oxygen, high tolerance of different functional groups, green reaction media and efficient recyclability make this organocatalyst suitable for both laboratory and industrial scale synthesis of bis (indolyl) methanes under very mild conditions.

 
Keyword(s): ALDEHYDE, INDOLE, BIS (INDOLYL) METHANE, SQUARIC ACID, WATER CHEMISTRY
 
References: 
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