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Paper Information

Journal:   GOVARESH JOURNAL   SUMMER 2014 , Volume 19 , Number 2; Page(s) 143 To 145.
 
Paper: 

MEASUREMENT OF SERUM TNF-α AS AN ACCURATE MARKER IN DIAGNOSING EXTRAHEPATIC BILIARY ATRESIA

 
 
Author(s):  FARIBORZI MOHAMMADREZA, FARAHMAND FATEMEH, FALLAHI GHOLAMHOSEIN, ASHTYANI MOHAMMADTAGHI, HASHEMI MASUMEH, KIUMARSI AZADEH, ALLAMEH MOHAMMAD MAHDY
 
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Abstract: 

Background: Most diagnostic tests for biliary atresia (BA) are invasive. This study evaluates the sensitivity and specificity of serum tumor necrosis factor-a (TNF-a) for diagnosing extra hepatic biliary duct atresia (EHBA) in infants.
Materials and Methods: Infants with cholestasis who were admitted to Children?s Medical Center Hospital were evaluated. A total of 50 infants (20 with EHBA and 30 non-EHBA) were included in this study. We evaluated the definite cause of cholestasis. Intra-operative cholangiography and, if possible, Kasai portoenterostomy were performed in infants with high suspicion for EHBA. Upon admission and prior to surgical intervention, infants had their serum TNF-
a levels measured by ELISA. We compared the mean TNF-a level between the two groups, in addition to the sensitivity and specificity of serum TNF-? for diagnosis of EHBA.
Results: This study enrolled 28 (56%) male and 22 (44%) female infants. Infants'' mean age was 2.87 months in the EHBA group and 2.6 months in the non-EHBA group. Sensitivity of serum TNF was 60% and its specificity was 76.66% for predicting EHBA. The positive predictive value was calculated as 63.1%, the negative predictive value was 74.1%, and accuracy was 70%. There was a significantly higher mean serum TNF-
a level in the EHBA group (220 pg/ml) compared to the non-EHBA group (79.8 pg/ml, p=0.023). Serum TNF-a cut off point for determining EHBA from non-EHBA was calculated as 80 pg/ml. Mean serum TNF-a in males (171.28 pg/ml) was more than females (90.80 pg/ml).
Conclusion: There was a significantly higher mean serum TNF-
a level in the EHBA group than the non-EHBA group. Serum TNF-? could be a proper test that has comparatively good sensitivity, specificity, positive predictive value and negative predictive value for predicting EHBA.

 
Keyword(s): TNF-α, EXTRAHEPATIC BILIARY ATRESIA, CHOLESTASIS, HEPATITIS
 
 
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Click to Cite.
APA: Copy

FARIBORZI, M., & FARAHMAND, F., & FALLAHI, G., & ASHTYANI, M., & HASHEMI, M., & KIUMARSI, A., & ALLAMEH, M. (2014). MEASUREMENT OF SERUM TNF-α AS AN ACCURATE MARKER IN DIAGNOSING EXTRAHEPATIC BILIARY ATRESIA. GOVARESH JOURNAL, 19(2), 143-145. https://www.sid.ir/en/journal/ViewPaper.aspx?id=404269



Vancouver: Copy

FARIBORZI MOHAMMADREZA, FARAHMAND FATEMEH, FALLAHI GHOLAMHOSEIN, ASHTYANI MOHAMMADTAGHI, HASHEMI MASUMEH, KIUMARSI AZADEH, ALLAMEH MOHAMMAD MAHDY. MEASUREMENT OF SERUM TNF-α AS AN ACCURATE MARKER IN DIAGNOSING EXTRAHEPATIC BILIARY ATRESIA. GOVARESH JOURNAL. 2014 [cited 2021May12];19(2):143-145. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=404269



IEEE: Copy

FARIBORZI, M., FARAHMAND, F., FALLAHI, G., ASHTYANI, M., HASHEMI, M., KIUMARSI, A., ALLAMEH, M., 2014. MEASUREMENT OF SERUM TNF-α AS AN ACCURATE MARKER IN DIAGNOSING EXTRAHEPATIC BILIARY ATRESIA. GOVARESH JOURNAL, [online] 19(2), pp.143-145. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=404269.



 
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