Paper Information

Journal:   ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)   DECEMBER 2013 , Volume 15 , Number 12; Page(s) 23 To 27.
 
Paper: 

STUDY ON THE SERUM TITER OF ANTI-HBS ANTIBODY OF THE VACCINATED STAFFS OF A HOSPITAL IN THREE CONSECUTIVE YEARS

 
 
Author(s):  MOHSENZADEH MEHDI, PIROUZI ALIYAR, JAFARI MOHAMMAD, AZADI MOHAMMAD, RAEISZADEH JAHROMI SAREH, AFKARI ROUHI*
 
* GERASH RESEARCH CENTER, SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, SHIRAZ, IRAN
 
Abstract: 

Background: Hepatitis B virus is one of the main factors causing acute and chronic hepatitis and hepatocellular carcinoma. Among others, healthcare workers are at the highest risk for exposure to hepatitis B virus. Vaccination against hepatitis B virus is one of the protective strategies but anti-HBs titer will be reduced in the sera of vaccinated people after some time. The aim of this study was to determine the titer of anti-HBs in the sera of vaccinated medical staffs in three consecutive years since administration of the last dose of hepatitis B vaccine.
Materials and Methods: This study was carried out on 90 Omidvar Hospital (Lar, Iran) medical staffs that had passed 3-4 months since the administration of the last dose of hepatitis B vaccine. All sera samples were tested for anti-HBs in an ELISA method. Finally, statistical analysis was performed using SPSS-16 software.
Results: This study was conducted in duration of 3 consecutive years on 90 medical staffs including 14.44% lab technicians, 10% obstetricians, 43.35% nurses, 6.665% specialists, 5.55% general practitioners and 20% maid staffs. While HBs Ab titer was measured as 87.7% (>100 mIU/ml) in the first year elapsed since the last dose of hepatitis B vaccination, it had been decreased to 55.4% after 3 years.
Conclusion: The results showed that re-vaccination of the medical staffs is quite necessary as anti-HBs titer had been decreased after 3 years and the desired immune response was seen only in 55.4% of the medical staffs.

 
Keyword(s): HEPATITIS B VIRUS, HBS ANTIBODY, HEPATITIS B VACCINE
 
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