Paper Information

Journal:   ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)   NOVEMBER 2013 , Volume 15 , Number 11; Page(s) 49 To 51.
 
Paper: 

EFFECT OF BIEBERSTEINIA MULTIFIDA DC. ROOT EXTRACT ON CHOLESTEROL IN MICE

 
Author(s):  KHAKPOUR SHAHRZAD*, AKHLAGHDOUST MEISAM, NAIMI SARA, MIRLOHI S. MOHAMMAD JAVAD, ABEDIAN MEDIA, SEYED FOROOTAN NAZILLA SADAT, FOROUGHI FATEMEH
 
* DEPARTMENT OF PHYSIOLOGY, MEDICAL SCIENCES RESEARCH CENTER, ISLAMIC AZAD UNIVERSITY, TEHRAN MEDICAL BRANCH, TEHRAN, IRAN
 
Abstract: 

Background: Hypercholesterolemia and atherosclerosis are the most common causes of mortality and disability, especially in developed countries. The aim of this research was to evaluate the effect of Biebersteina multifida DC. root extract on HDL and LDL blood level.
Materials and Methods: In this experimental study, 35 male Balb/c mice were randomly divided in five groups such control, sham, and experimental groups which received Biebersteina multifida DC. root extract with the doses of 4, 5 and 10 mg/kg; three last groups were daily fed orally, for thirty days. HDL and LDL blood serum levels were measured, in the last day and compared with control and sham groups.
Results: The results after 30 days gavage of 4, 5 and 10 mg/kg of Biebersteinia Multifida DC. root extract showed that the root extract decrease of LDL level significantly. The doses of 4 and 5 mg/kg of the root extract were the effective dose in decreasing the serum HDL level. However, 10 mg/kg dose of root extract has no significant effect on HDL level in comparison with control and sham groups.10 mg/kg of root extract had the maximum effect on reducing LDL level.
Conclusion: According to this study, it is suggested that the root extract of Biebersteinia multifida DC. Can be efficient to reduce the level of HDL and LDL in blood serum.

 
Keyword(s): BIBERSTEINIA MULTIFIDA DC, HDL, LDL, MICE
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 85
 
Latest on Blog
Enter SID Blog