Paper Information

Journal:   BULLETIN OF EMERGENCY AND TRAUMA BEAT   2014 , Volume 2 , Number 1; Page(s) 22 To 26.
 
Paper: 

THE EFFECTS OF INTRAVENOUS ACETAMINOPHEN ON PAIN AND CLINICAL FINDINGS OF PATIENTS WITH ACUTE APPENDICITIS; A RANDOMIZED CLINICAL TRIAL

 
 
Author(s):  MOUSAVI SEYED MOHSEN*, PAYDAR SHAHRAM, TAHMASEBI SEDIGHEH, GHAHRAMANI LEILA
 
* TRAUMA RESEARCH CENTER, SHAHID RAJAEE (RMTIAZ) TRAUMA HOSPITAL, SHIRAZUNIVERSITY OF MEDICAL SCIENCES, SHIRAZ, IRAN
 
Abstract: 

Objective: To determine the effects of intravenous Acetaminophen (Apotel?) on pain severity and clinical findings of peritonitis in patients with acute appendicitis.
Methods: This randomized cross-over clinical trial was carried out duringa 6-month period from August 2012 to February 2013 and comprised 107 patients diagnosed with acute appendicitis. Patients were randomly assigned to received placebo (n=54) or Apotel
? (n=53). Patients were evaluated before, 30 minutes, 1 hour and 4 hours after administration of Apotel? or placebo, and were told to fill in two forms. The first form required patientsto measure their painintensity according to visual analogue scale (VAS). The second form was filled by a surgeon who examined the patients and recorded his or her findings using Alvarado score criteria for diagnosis of acute appendicitis at foregoing time points.
Results: Of 72 patients, 37 (51.4%) were men and 35 (48.6%) were women. The mean age of the patients was 34.1±13.5 years. The mean pain score in 107 patients included in this study was 7.96±2.3. Those who received Apotel
? had significantly lower pain scores when compared to placebo at 30 minutes (p<0.001), 1 hour (p<0.001) and 4 hours of administration. There was no significant difference between two study groups regarding the frequency of Alvarado score; however the frequency of fever was significantly lower in those who received Apotel? (p<0.001).We found that Apotel® was not associated with resolved physical findings of acute appendicitis in different time intervals.
Conclusion: Apotel
? does not affect the clinical findings of acute appendicitis and dos not interfere with the accurate diagnosis. Therefore, it could safely be used as a reliable pain relieving agent, in patients with acute appendicitis.

 
Keyword(s): ACUTE APPENDICITIS, APOTEL®, CLINICAL FINDINGS, ANALGESIC
 
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