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Paper Information

Journal:   AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)   OCTOBER-DECEMBER 2014 , Volume 6 , Number 4; Page(s) 192 To 199.
 
Paper: 

NEW INSIGHTS INTO VEGF-A ALTERNATIVE SPLICING: KEY REGULATORY SWITCHING IN THE PATHOLOGICAL PROCESS

 
 
Author(s):  DEHGHANIAN FARIBA, HOJATI ZOHREH*, KAY MARYAM
 
* DEPARTMENT OF BIOLOGY, FACULTY OF SCIENCES, UNIVERSITY OF ISFAHAN, ISFAHAN, IRAN
 
Abstract: 

Vascular endothelial growth factor (VEGF-A) is one of the most important regulatory factors in pathological and physiological angiogenesis. Alternative splicing is a complicated molecular process in VEGF-A gene expression which adds complexity to VEGF-A biology. Among all VEGF-A exons, alternative splicing of exon 8 is the key determinant of isoform switching from pro-angiogenic VEGF-xxx to anti-angiogenic VEGF-xxxb. This is known as a key molecular switching in many pathological situations. In fact, the balance between VEGF-xxx and VEGF-xxxb isoforms is a critical controlling switch in both conditions of health and disease. Here, the properties of VEGF-xxx and VEGFxxxb isoforms were discussed and their regulatory mechanism and their roles in certain pathological processes were evaluated. In summary, it was suggested that C-terminal VEGF-A alternative splicing can provide a new treatment opportunity in angiogenic diseases.

 
Keyword(s): ALTERNATIVE SPLICING, ANGOIGENESIS, DISEASE, HEALTH, VASCULAR ENDOTHELIAL GROWTH FACTOR A
 
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