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Paper Information

Journal:   IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)   AUGUST-SEPTEMBER 2014 , Volume 16 , Number 3; Page(s) 205 To 210.
 
Paper: 

EFFECT OF SIX WEEKS ENDURANCE TRAINING ON TUMOR TISSUE IL-10 CYTOKINE LEVELS IN BREAST CANCER BEARING MICE

 
 
Author(s):  SHIRI Y., AGHA ALINEJAD H.*, GHARAKHANLOU R., AMANI SHALAMZARI S., SAEI M.A.
 
* FACULTY OF HUMANITIES, TARBIAT MODARES UNIVERSITY, TEHRAN, I.R. IRAN
 
Abstract: 

Methods: The twenty female Balb/c mice (6-8 week-old, 14±2 gr weights) were divided to two control and exercise groups. After orientation in the environment, estrogen-receptor dependent breast cancer cells (MC4-L2) were injected to them and exercise group performed endurance exercise for 6 weeks. After appearance of the tumor, the length and width of the tumor were measured by a digital caliper once a week. Finally, the mice were sacrificed; tumor tissue was removed and immediately frozen and kept in -70oC. Tumor sample was homogenized and levels of IL-10 were measured and quantified using ELISA method.
Results: There was significant increase on level of IL-10 in exercise group than control group (P
£0.05). Tumor volume reduced in exercise group than control group. The results showed that the amount of IL-10 significantly increased in the exercise group compared to control group Also reduction in tumor volume observed in the exercise group compared to control group.
Conclusion: Increased levels of IL-10 was in parallel to reduction in tumor volume, which shows that exercise lead to reduction tumor growth through increased levels of this cytokine. Angiogenesis is a prerequisite for continued growth and spread of tumors, therefore, increased levels of IL-10 that is an angiogenesis cytokine in the exercise group compared to the control group shows exercise can inhibit from tumor growth by modulating cytokine profile within the tumor microenvironment.

 
Keyword(s): BREAST CANCER, ENDURANCE TRAINING, INTERLEUKIN, 10, TUMOR VOLUME
 
 
References: 
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Click to Cite.
APA: Copy

SHIRI, Y., & AGHA ALINEJAD, H., & GHARAKHANLOU, R., & AMANI SHALAMZARI, S., & SAEI, M. (2014). EFFECT OF SIX WEEKS ENDURANCE TRAINING ON TUMOR TISSUE IL-10 CYTOKINE LEVELS IN BREAST CANCER BEARING MICE. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 16(3), 205-210. https://www.sid.ir/en/journal/ViewPaper.aspx?id=403158



Vancouver: Copy

SHIRI Y., AGHA ALINEJAD H., GHARAKHANLOU R., AMANI SHALAMZARI S., SAEI M.A.. EFFECT OF SIX WEEKS ENDURANCE TRAINING ON TUMOR TISSUE IL-10 CYTOKINE LEVELS IN BREAST CANCER BEARING MICE. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM). 2014 [cited 2021May10];16(3):205-210. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=403158



IEEE: Copy

SHIRI, Y., AGHA ALINEJAD, H., GHARAKHANLOU, R., AMANI SHALAMZARI, S., SAEI, M., 2014. EFFECT OF SIX WEEKS ENDURANCE TRAINING ON TUMOR TISSUE IL-10 CYTOKINE LEVELS IN BREAST CANCER BEARING MICE. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), [online] 16(3), pp.205-210. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=403158.



 
 
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