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Paper Information

Journal:   NASHRIEH SHIMI VA MOHANDESI SHIMI IRAN (PERSIAN)   SUMMER 2013 , Volume 32 , Number 2 (68); Page(s) 1 To 13.
 
Paper: 

STUDIES OF THE INTERACTION OF NI (II) COMPLEXES BEARING PLANAR AROMATIC LIGANDS WITH CALF THYMUS DNA

 
 
Author(s):  ESMAEILZAEI ZOHREH*, SABOURY AIL AKBAR, MANSOURI TORSHIZI HASAN, SAEIDIFAR MARYAM, DIVSALAR ADELEH
 
* ISLAMIC AZAD UNIVERSITY, SCIENCE & RESEARCH BRANCH, ZAHEDAN, I.R. IRAN
 
Abstract: 

Three Nickel (II) complexes of formula [Ni (en)2] (N03)2 (a), [Ni (bpy)2](N03)2 (b) and [Ni (phen)2] (N03)2 (c) (where en=ethylenediamine, bpy=2,2 bipyridine and phen=1,10 phenanthroline) were prepared. The structure of these complexes have been characterized by spectroscopic methods such as infrared, ultraviolet visible and nuclear magnetic resonance and conductivity measurements and elemental analysis. Interaction of these three complexes with calf thymus DNA were carried out using ultraviolet- visible, fluorescence and jell- filterationtachniques. These complexes can denature the DNA at quite low concentrations. Complexes band c having aromatic surface presumably intercalate in DNA. Moreover complex c can cleave the DNA into two parts and interact with both.

 
Keyword(s): NICKEL COMPLEXES, INTERACTION WITH DNA, INTERCALATION
 
References: 
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