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Paper Information

Journal:   RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)   2003 , Volume 8 , Number 3 (33); Page(s) 187 To 190.
 
Paper: 

THE EFFICACY OF LAMOTRIGINE ADJUNCTIVE THERAPY IN LENNOX-GASTAUT SYNDROME

 
 
Author(s):  BARZEGAR M.*, TONEKABONI H., GHOFRANI M.
 
* Department of Pediatrics, Tabriz University of medical Sciences
 
Abstract: 

Background: Lennox-Gastaut Syndrome (LGS) is one of the intractable epilepsies of childhood causing morbidity in patients who suffer this type of epilepsy. In this study the efficacy of lamotrigine (LTG) in LGS has been evaluated in children referring to Mofid hospital between 1997-98.
Materials and methods: For this clinical trial, eighteen 4-12 year old children were selected. All of whom were resistant to conventional anti epileptic drugs. They have used at least five different categories of antiepileptic drugs but experienced at least one attack per day. Dose of LTG and its titration was adjusted according to the dosage of other antiepileptic drugs. Efficacy of Lamotrigine was judged upon reduction of seizure frequency after 3 months of drug consumption compared to previous 3 months. Meanwhile, drug safety was evaluated based upon effects reported by parent's, clinical findings and results of periodic laboratory test.
Results: Sixty percent of the patients (9 of 15) had more than 50% reduction in seizure frequency. Rash was noted in 17% of the patients (3 of 18) which necessitated discontinuation of LTG. Besides skin eruption, no any abnormal findings were noted in clinical or laboratory parameters.
Conclusion: The results of our study indicate that Lamotrigine add-on-drug therapy is both effective and safe in patients who suffered LGS.

 
Keyword(s): LAMOTRIGINE, LENNOX-GASTAUT SYNDROME, PEDIATRIC EPILEPSY
 
References: 
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