Paper Information

Journal:   RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)   2003 , Volume 8 , Number 3 (33); Page(s) 171 To 176.
 
Paper: 

AQUEOUS EXTRACT OF PLANTAGO MAJOR LEAVES IN PREVENTING CHEMOTHERAPY-INDUCED STOMATITIS

 
 
Author(s):  POURESMAEIL Z.*, SHOURI BIDGOLI A.R., ZARGARI A.
 
* Faculty of Nursing and Midwifery, Shaheed Beheshti University of medical Sciences
 
Abstract: 

Background: Chemotherapy can be associated with stomatitis. Previous therapeutic approaches have been failed to result in satisfactory outcomes. The present study was conducted in three different hospitals in Tehran to determine the efficacy of aqueous extract of Plantago major leaves in preventing chemotherapy-induced stomatitis.
Materials and methods: 60 patients have been enrolled for this single blind clinical trial. A checklist was used to determine the mouth inflammation status prior to the therapy, meanwhile, demographic characteristics such as age and sex were also recorded. Patients were distributed in 3 groups of experiment (Aqueous extract of Plantago major), control (normal saline 5%), and placebo (distilled water). They used the aforementioned liquids thrice a day for 21 days following the chemotherapy. The mouth inflammation status was determined in days 7th, 14th, and 21st.
Results: On the 21st day the following results have been obtained; in the experiment group 75% were normal, 20% and 5% had ulcer of first and second grade, respectively. In normal saline group 15% were normal, 10, 70, and 5% had ulcer of 1st, 2nd, and 3rd grade, respectively. These figures were 10, 15, 55, and 20% in the placebo group, respectively. There was a significant correlation between the experiment group and the other two groups in the 7th day (P=0.001), 14th day (P=0.003), and 21st day (P=0.0001) regarding the severity of stomatitis.
Conclusion: Aqueous extract of plantago major leaves could be helpful in the treatment of chemotherapy-induced stomatitis.

 
Keyword(s): CHEMOTHERAPY, STOMATITIS, AQUEOUS EXTRCT OF PLANTAGO MAJOR LEAVES
 
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