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Paper Information

Journal:   RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)   2003 , Volume 8 , Number 3 (33); Page(s) 233 To 238.
 
Paper: 

CORRELATION BETWEEN TUMOR MARKERS AND HEMODIALYTIC PATIENTS CHARACTERISTICS AND RENAL TRANSPLANTATION

 
 
Author(s):  MOHKAM M.*, DERAKHSHAN A., AMID M.H., VELAEI N.
 
* Department of Pediatrics, Shaheed Beheshti University of Medical Sciences
 
Abstract: 

Background: With respect to the increased number of renal transplantation and reports of false positive increment of tumor markers in the affected patients, the present study was conducted in Namazi hospital to determine the correlation between the tumor markers and hemodialytic patients' characteristics and renal transplantation.
Materials and Methods: For this descriptive study, 30 hemodialytic children and 29 patiets who have referred for renal transplantation were enrolled. None of these have a definite malignancy. The following tumor markers were evaluated: CEA, PSA, AFP, CA-125, and CA-19-9 using ELISA technique. Then, in hemodialytic patients, the tumor markers" level were compared with sex, age, etiology of renal disease, duration of renal disease, duration of hemodialysis, and blood pressure. In patients referring for renal transplantation the tumor markers" level were compared with age, type of graft, duration of renal disease, hemodialysis prior to transplantation, number of rejections, grafted kidney performance, blood pressure, and blood group. Their correlation was determined.
Results: the mean age was 16.5±6.2 years. In hemodialytic patients there was a significant correlation between PSA and age, CA 19-9 and duration of renal disease, and CA-125 and adequacy of dialysis (P<0.007, P<0.032, and P<0.003, respectively). In patients referring for renal transplantation, there was a significant correlation between PSA and CA 15-3 with duration of hemodialysis prior to the transplantation (P<0.005), CA-125 with systolic blood pressure and number of rejections (P<0.009), and CA 19-9 with diastolic blood pressure (P<0.01).
Conclusion: Results have revealed that there exists a correlation between the tumor markers and patients characteristics. Further analytical studies are highly recommended.

 
Keyword(s): TUMOR MARKER, RENAL TRANSPLANTATION, HEMODIALYSIS
 
References: 
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