Paper Information

Journal:   RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)   2003 , Volume 8 , Number 3 (33); Page(s) 213 To 218.
 
Paper: 

COMPARISON OF QUALITY OF DIALYSIS AND NUTRITIONAL STATUS IN DIABETIC END-STAGE RENAL DISEASE AND NON DIABETIC INDIVIDUALS

 
 
Author(s):  SOULATI M.*, RAEISZADEH F., HAJPOUR R., RAHBAR KH., AZIZI F.
 
* Endocrine Research Center, Shaheed Beheshti University of Medical Sciences
 
Abstract: 

Background: Diabetes is now the most common cause of new patients requiring renal replacement therapy. Patient survival in diabetics on maintenance dialysis is lower than that seen in nondiabetics with end-stage renal failure due to other disease. The inadequacy of dialysis and decrease in nutritional status are important contributors to the unfavorable outcome in diabetics. This study aims at assessing the adequacy of dialysis and nutritional status in diabetic patients and comparing them with nondiabetics in an Iranian population.
Materials and methods: Thirty-nine patients with diabetic nephropathy and end-stage renal disease were compared with seventy-two age and sex matched nondiabetic patient with end-stage renal disease. Patients were selected from teaching hospitals of Shaheed Beheshti University of Medical Sciences, Tehran, Iran. Clinical examinations and anthropometric measurements were done for all patient. A fasting predialyssis and 2-minute postdialysis blood samples were obtained and serum BUN, creatinine, cholesterol, triglycerides, HDL-C were measured at Research Laboratory of Endocrine Research Center. Adequacy of dialysis (KT/V) and urea reduction ratio (URR) were calculated for all patients.
Results: Age (60±9 vs 56±14 years), sex, body mass index (BMI) and waist-to-hip ratio were not significantly different between diabetic and non diabetic groups. In nondiabetic patients, increased concentration of serum creatinine (5.1±0.9 vs 4.6±0.9 mg/dl, P<0.05) and decreased FBS (94±20 vs 154±40 mg/dl; P<0.05) was observed compared to diabetic group. Serum albumin, predialysis BUN, total cholesterol, triglycerid, HDL-C, Kt/v and URR did not significantly differ between the two groups.
Conclusion: Results have revealed that there was not a significantly difference in Kt/v between two groups. Lower serum creatinine level in diabetic patients as compared with nondiabetics reflects lower lean body weight (LBW) in these patients and is associated with poor prognosis.

 
Keyword(s): END STAGE RENAL DISEASE, DIABETIC MELLITUS, DIALYSIS
 
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