Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   IRANIAN INTERNATIONAL JOURNAL OF SCIENCE   Spring 2003 , Volume 4 , Number 1; Page(s) 1 To 12.
 
Paper: 

EVALUATION OF THE TERATOGENICITY OF MORPHINE SULFATE BY ORAL ADMINISTRATION IN BALB/C MICE

 
 
Author(s):  SHAMS LAHIJANI M., RAMEZANI M.
 
* 
 
Abstract: 
The teratogenic effects of morphine sulfate exposure, during pregnancy, were studied in Balb/C mice, in three different concentrations of 0.01, 0.05 and 0.1 mg/ml, using oral administration. For addiction, the drug was provided in increasing concentrations for 3 weeks (n=26-63); one control and seven experimental groups, for every concentration were used, which included non-administered (untreated) and administered (treated) females mated with treated and untreated males. For the first time, cesarean sections were performed on the end of gestation; number of fetuses and resorption sites were recorded. Fetuses and placentas were examined externally and preserved for subsequent visceral and skeletal examinations. Fetal morphine sulfate exposure was associated with significant reduction in size of litters (P<0.05) weight (P<0.001), length of crown-rump (P<0.001, P<0.005) and placenta weight (P<0.001), P<0.005) and diameter (P<0.001), in two doses of 0.01 and 0.05 mg/ml. With using 0.1 mg/ml, only some experimental groups showed significant decrease (P<0.05). All exposed-groups showed an increase in the percentage of abnormalities compared to control groups (P<0.001). Staining the skeletal structures showed an extra rib in fetuses. Results revealed that morphine possess: 1) teratogenic potential on developing mice fetuses, in doses of 0.01, 0.05 and 0.1 mg/ml; 2) male-exposure to morphine has lower disruptive effects on embryos than female exposure, and 3) teratogenic effects of morphine increase with lower doses.
 
Keyword(s): MOUSE EMBRYO, TERATOGENICITY, MORPHINE SULFATE
 
References: 
  • ندارد
 
  Yearly Visit 76
 
Latest on Blog
Enter SID Blog