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Paper Information

Journal:   RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)   SPRING 2003 , Volume 8 , Number 1 (31); Page(s) 7 To 13.
 
Paper: 

PROGNOSTIC SIGNIFICANCE OF HER-2 ONCOPROTEIN IN PREMENOPAUSAL NODE POSITIVE BREAST CANCER

 
 
Author(s):  MORTAZAVI S.H., AZADEH P.*, VALAEI NASER
 
* department of Radiotherapy - Oncology, Shaheed Beheshti University of Medical Sciences
 
Abstract: 

Background: The influence of HER-2 on prognosis of breast cancer is a matter of controversy. The purpose of this study was to investigate the long-term prognostic significance of HER-2 oncoprotein expression in breast cancer.
Material and methods: 103 premenopausal node positive breast cancer patients who received adjuvant treatment between 1004 and 1997 were enrolled in this study. The immunostaining for HER-2 was performed on formaldehyde solution fixed paraffin embedded sections of patients. HER-2 positive subjects were considered as the case group, whereas those negative for HER-2 compromised the control group. Prognosis was determined according to the overall survival (OS) and disease free surveillance (DFS).
Results: Groups were similar according to the age, pathology, stage of the disease, type of surgery, and adjuvant. 30 patients (29.3%) revealed a positive staining for HER-2 oncoprotein. Positive staining correlated with absence of estrogen receptor content (P<0.009). The difference in survival between two groups was significant for overall and disease free survival (P<0.004). HER-2 positive patients who underwent oophorectomy revealed better HER-2 negative patients. In a multivariate analysis, HER-2 expression was an independent prognostic factor.
Conclusion: This study supports the association of HER-2 oncoprotein expression with poor prognosis in node-positive premenopausal breast cancer. Oopherrctomy must be considered as an adjuvant treatment for HER 2+patients. Further multicentric studies would precisely clarify the association.

 
Keyword(s): BREAST CANCER, HER-2 ONCOPREOTEIN, ADJUVANT THERAPY
 
References: 
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