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Paper Information

Journal:   RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)   SPRING 2003 , Volume 8 , Number 1 (31); Page(s) 1 To 5.
 
Paper: 

BONE MINERAL DENSITY IN 10-20 YEAR OLD PATIENTS WITH THALASSEMIA MAJOR AND ITS FELATED FACTORS, TEHRAN 2001

 
 
Author(s):  TABATABAEIFAR M.*, ABD ELAH SHAMSHIRSAZ A.R., BAKHIRNIA M.R., KAMGAR M., MORADI LAKEH M., ALEH BOUYE M., MOOSAVI F., AZAR KEYVAN A., KIMIAGAR SEYED MASOUD, HASHEMI R., BOOZARI N., POURZAHED GILANI N., ABDOLLAH SHAMSHIRSAZ A.H.
 
* Shaheed Beheshti University of Medical Sciences
 
Abstract: 

Background: Reduced bone density is a well-known complication of thalassemia major. This problem has been manifested more commonly due to longer life of affected individuals. The present study was conducted to determine the prevalence of reduced bone mineral density in 10-20 year old patients with thalassemia major and its related factors, Tehran, 2001.
Materials and methods: For this cross sectional study, 208 patients with thalassemia major undergoing blood transfusion in Tehran were included. Bone mineral density of lumbar and femoral bones was determined by dual X-ray absorptiometery technique. Those who have Z score of-1 to -2.5 (compared with age-and sex-matched controls) were considered as osteopenic; however those with Z score of less than-2.5 were osteoporotic.
Results: Osteoporosis of lumbar and femoral bones was reported in 50.2 and 11% of subjects. Mean age of patients with osteoporotic lumber bones was significantly higher than others (P<0.001). Testis size in boys and breast size in girls was significantly correlated with Z score. Growth percentiles of weight for age, weight for age and height for weight were significantly correlated with lumbar bone density.
Conclusion: The association between age and bone density reveals the effective factors influencing the mineral contents over a period. Meanwhile, delay in puberty could be an influential the mineral contents over a period. Meanwhile, delay in puberty could be an influential factor. Preventing methods (hormone therapy and modified diet) as well as early diagnosis and treatment are strongly recommended.

 
Keyword(s): BONE DENSITY, THALASSEMIA MAJOR, OSTEOPOROSIS
 
References: 
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