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Paper Information

Journal:   INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)   March 2005 , Volume 3 , Number 1; Page(s) 18 To 24.
 
Paper: 

STRENUOUS, FATIGUING EXERCISE: RELATIONSHIP OF CORTISOL TO CIRCULATING THYROID HORMONES

 
 
Author(s):  MOORE A.W., TIMMERMAN S., BROWNLEE KK., RUBIN DA., HACKNEY AC.*
 
* Department of Nutrition, School of Public Health, University of North Carolina, USA
 
Abstract: 
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The purposes of this study were to dete3rmine how strenuous, fatiguing running exercise affects: 1) selective thyroid hormones, and 2) the relationship of glucocorticoid responses to such exercise with thyroid hormones.
Materials and Methods: Well-trained subjects (n=12) performed a treadmill run at individual ventilatory threshold (74±8% of maximal aerobic capacity) until volitional fatigue (68.3±12.3 min). Blood samples were taken before exercise as a resting baseline (B0), at fatigue (FG), 90-minutes into recovery (90mR), and 24-hours into recovery (24hR). Blood was analyzed for free T3 (fT3), free T4 (fT4), thyroid-stimulating hormone (TSH), and cortisol.
Results: Significant increases in fT3 and TSH concentrations between B0 and FG (fT3= 1.70 pg/mL vs. 2.08 pg/mL; TSH=1.69 µIU/mL vs. 2.43 µIU/mL, p<0.01) were observed, but by 24hR, significant decreases from B0 were present (fT3 and TSH=1.48 pg/mL and 1.20 µIU/ml, respec-tively; p<0.05).
FG fT4 demonstrated a non-significant increase from B0 (FG fT4=1.84 ng/dL) but by 24hR fT4 was significantly lower than FG (24hR fT4=1.67 ng/dL, p<0.01). FG cortisol levels increased significantly from B0 (476.1 to 843.9 nmol/L, p <0.01) and remained elevated at 90mR (892.2 nmol/L) but returned to baseline by 24hR. Spearman correlation analysis yielded a signifi-cant negative correlation between FG cortisol and 24hR TSH (r= -0.65, p<0.05). A strong trend was also noted between FG cortisol and 24hR ft3 (r = -0.55, p<0.07).
Conclusion: These findings suggest that exhaustive exercise decreases the level of selective thy-roid hormones by 24 hours into recovery, and that cortisol levels after fatiguing exercise are negatively related to circulating TSH at this point into recovery.[Int J Endocrinol Metab 2005.1:18-24]
 
Keyword(s): STRESS, GLUCOCORTICOIDS, FATIGUE, THYROID FUNCTION, EXERCISE
 
 
References: 
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Click to Cite.
APA: Copy

MOORE, A., & TIMMERMAN, S., & BROWNLEE, K., & RUBIN, D., & HACKNEY, A. (2005). STRENUOUS, FATIGUING EXERCISE: RELATIONSHIP OF CORTISOL TO CIRCULATING THYROID HORMONES. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 3(1), 18-24. https://www.sid.ir/en/journal/ViewPaper.aspx?id=33379



Vancouver: Copy

MOORE A.W., TIMMERMAN S., BROWNLEE KK., RUBIN DA., HACKNEY AC.. STRENUOUS, FATIGUING EXERCISE: RELATIONSHIP OF CORTISOL TO CIRCULATING THYROID HORMONES. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM). 2005 [cited 2021May09];3(1):18-24. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=33379



IEEE: Copy

MOORE, A., TIMMERMAN, S., BROWNLEE, K., RUBIN, D., HACKNEY, A., 2005. STRENUOUS, FATIGUING EXERCISE: RELATIONSHIP OF CORTISOL TO CIRCULATING THYROID HORMONES. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), [online] 3(1), pp.18-24. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=33379.



 
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