Paper Information

Journal:   ARCHIVES OF RAZI INSTITUTE   December 2003 , Volume - , Number 56; Page(s) 103 To 108.
 
Paper: 

AN IN VIVO ASSAY FOR BILILOGICAL ACTIVITY OF SYNTHESIZED RECOMBINANT HUMAN GROWTH HORMONE

 
 
Author(s):  PARVANEH TAFRESHI A.*, SANATI M.H.
 
* Physiology Dept., The National Research Center for Genetic Engineering and Biotechnology of Iran,Tehran, Iran
 
Abstract: 

The biological activity of the recombinant growth hormone (GH) synthesized in the national research center for Genetic Engineering and Biotechnology (NRCGEB) was evaluated in vivo. In this regard a hypophysectomized rat model was required. Using a Para pharyngeal approach the sphenoid bone of rats was drilled and the hypophysis was out successfully by aspiration following a 7- day recovery period rate were injected subcutaneously either with the recombinant human GH or the Novo as standard . The results shoe that both hormones have an equal biological activity and resulted in a 100% growth increment equal to that in untreated intact rats indicating that the recombinant GH can be introduced as a good replacement of endogenous GH.

 
Keyword(s): RECOMBINANT HUMAN GROWTH HORMONE, HYPOPHYSECTOMY, RAT
 
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