Paper Information

Journal:   ARCHIVES OF RAZI INSTITUTE   December 2003 , Volume - , Number 56; Page(s) 71 To 80.
 
Paper: 

ASSOCIATION BETWEEN SERUM IL - 4 LEVELS AND CYST RELAPSING IN CYSTIC ECHINOVOCCOSIS

 
 
Author(s):  DALIMI A.*, GHAFFARIFAR FATEMEH, ZAVARAN HOSSEINI A.
 
* Parasitology Dept., Medical Sciences Faculty, Tarbiat Modarres University, Tehran, Iran
 
Abstract: 

IFN - γ and IL - 4 levels of peripheral blood mononuclear cell (PBMC) cultures and sera of the cystic echinococcosis patients with primary and relapsed infections were compared in this regard PBMC of the patients and controls were cultured in RPMI and stimulated with different hydatid fluid antigens of (SHF. PH5PPT. B-Ag, F1 and F2) IFN γ and IL - 4 of the culture supernatants as well as the sera of echinococcosis patients were evaluated by ELISA. The results indicate that the level of IL - 4 produced by PBMC of the patients was higher than that of healthy group and the difference was significant. The levels of IL - 4 in PBMC culture and sera of the patients with relapsed hydatidosis were significantly higher than those with primary infection means the immune response pattern of the patients who have not received any ant parasitic drug after surgery, may shift toward th2 activation and susceptibility to the infection. Contrary the levels of IFN γ - produced by PBMC and in sera of the patients treated surgically once do not differ significantly with those treated two times of more.

 
Keyword(s): ECHINOCCUS GRANULISYS, CYTOKINE. IFN - Γ, IL - 4, CYST RELAPSING
 
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