Paper Information

Journal:   ARCHIVES OF RAZI INSTITUTE   December 2003 , Volume - , Number 56; Page(s) 23 To 35.
 
Paper: 

EFFICACY OF EXPERIMENTAL INACTIVATED VACCINE FOR INFECTIOUS BROUCHITIS DISEASE

 
 
Author(s):  GHADAKCHI H.*, DADRAS H., POURBAKHSH S.A., HOSSEINI M.
 
* Razi Vaccine & Serum Research Institute, Mashed, Iran
 
Abstract: 

Experimental oil- emulsion vaccine was formulated with a ration of one part of 0.05% β- propiolactone inactivated antigen and four parts oil adjuvant ISA -70. Four hundred white. HY - Line (W-36) chicks were reared in four groups. Group 1 and 2 were vaccinated by live attenuated H 120 at day 10 and reared experimental oil -emulsion and commercial oil - emulsion vaccines respectively. At this time group 3 was received single dose of experimental oil -emulsion vaccine and group 4 was unvaccinated control. At week 29 all of groups were challenged by 0.25.107 EID50 bird of infected allantoic fluid when they were on peak of production. All groups were bled frequently and the sera were assayed by ELISA and AGLD tests. Clinical signs and high percentage drop in egg production in groups 3 and 4 were noted moreover. On virus and or viral antigen in the trachea of groups 1 and 2 were detected at days 5 and 10 postchallenge. The results of clinical observation egg production virus isolation and detection in the trachea and levels of antibody suggested that layers vaccinated with a combination of live attenuated and the experimental inactivated vaccines had the highest protection.

 
Keyword(s): INFECTIOUS BRONCHITIS, OIL-EMULSION VACCINE Β- PROPIOLACTONE, AGID ELISA
 
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