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Paper Information

Journal:   IRANIAN BIOMEDICAL JOURNAL   July 2003 , Volume 7 , Number 3; Page(s) 99 To 106.
 
Paper: 

MODIFICATION OF NIFEDIPINE INHIBITORY EFFECT ON CALCIUM SPIKE AND LTYPE CALCIUM CURRENT BY ETHANOL IN F1 NEURON OF HELIX ASPERSA

 
 
Author(s):  *, , JANAHMADI M.
 
* 
 
Abstract: 
There is strong evidence demonstrating that nifedipine dissolved in ethanol selectively ‎inhibits only L-type Ca^2+ current. In addition, acute ethanol exposure reduces ‎voltage-dependent calcium currents. In the present study, we investigated the ‎antagonistic effect of fixed concentration of nifedipine dissolved in different ‎concentration of ethanol on L-type Ca^2+ current. In a Na^+-K^+ free solution, ‎nifedipine dissolved in 60 and 120 mM ethanol decreased resting membrane potential ‎of Ca^2+ spikes and caused a significant reduction in amplitude, duration and an ‎increase in threshold of Ca^2+ spikes. Furthermore, Ca^2+ current was inhibited by ‎ethanol in a concentration-dependent manner, so that the reduction of L-type Ca^2+ ‎current by nifedipine/60 and 120 mM ethanol was statistically significant. Meanwhile; ‎ethanol concentration-dependent response of Ca2+ currents was observed at its late ‎component in more positive potentials. These results may be consistent with ethanol-‎dependent inhibition of L-type Ca^2+ currents and ethanol-dependent enhancement of ‎a Ca^2+-activated potassium current‏.‏
 
Keyword(s): ETHANOL, NIFEDIPINE, CA^2+ SPIKES, L-TYPE CA^2+ CURRENT, F1 NEURON
 
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