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Paper Information

Journal:   IRANIAN JOURNAL OF MEDICAL SCIENCES (IJMS)   December 2003 , Volume 28 , Number 4; Page(s) 200 To 200.
 
Paper: 

GENDER DIFFERENCE IN ENDOTHELIAL PERMEABILITY OF AORTA IN RABBITS CONSUMING NORMAL OR HIGH-CHOLESTEROL DIETS

 
 
Author(s):  NEMATBAKHSH MAHDI, HABIBI H.R., SOLTANI N., HAYATDAVOODI P., BORJAN L., NAJI H.
 
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Abstract: 
The endothelial permeability of aorta (EPA) is influenced by atherosclerosis. Whether the physiological difference in EPA is a sex-dependent phenomenon remains to be determined. The objective of this study was to determine the EPA difference between male and female rabbits. An experimental model was designed to obtain 4 groups of animals. The ovariectomized rabbits were fed with normal (group I) and 1% cholesterol-rich diets (group III). The male rabbits also received normal (group II) and cholesterol-rich diets (group IV). After 5 wks, the EPA was measured by Evan Blue (EB) dye uptake method. The EB uptake was significantly (p<0.05) lower in females, regardless of the diet they used. In groups I to IV, the mean±SD EB uptake was 4.83±2.06, 15.15±2.91, 7.01±2.40, and 20.58±3.62 pg/g weight of aorta, respectively. The lower EPA in females may play a role in reducing the risk of development of atherosclerosis. Iran J Med Sci 2003; 28(4): 200-202.
 
Keyword(s): O PERMEABILITY O AORTA -SEX
 
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