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Paper Information

Journal:   JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES   Summer 2003 , Volume 12 , Number 46; Page(s) 7 To 17.
 
Paper: 

A COMPARATIVE STUDY OF THE EFFECTS OF INTRAPERITONEAL AND INTRACEREBELLAR VENTRICLE INJECTION OF PICROTOXIN AND BICCUCULINE ON REGULATION OF BLOOD GLUCOSE CONCENTRATION IN MICE

 
 
Author(s):  GHIRVANI Z.*, POURGHOLAMI M.H.
 
* 
 
Abstract: 

Introduction: GABA is a inhibitory neurotransmitter in CNS that plays an important role in the regulation of blood glucose. There have been reports that GABA-A receptors might cause a reduction in the concentration of blood glucose by increasing the insulin plasma and decreasing the glucagon and somatostatine.
Objective: This study was carried out to compare the effects of interaperitoneal and intracerebellar ventricle injection of Picrotoxin and Biccuculine on regulation of blood glucose concentration in mice.
Materials and methods: In this experimental study, male albino mice weighing 20-30 grams were used. Serial blood collection from each animal was done by retro-orbital sinus puncture, and glucose concentration was measured using O-toluidin. In this experiment, the effect of different doses (IP and ICV) injection of Picrotoxin and Biccuculine on blood glucose was studied. One-way variance analysis and t-test were adopted in statistical analysis of the collected data.
Results: The results indicated that IP and ICV injection of Picrotoxin and Biccuculine induce significant increase of blood glucose concentration in two groups (P<0.05). Another point is that increased blood glucose concentration is observed until 45-th minute in all doses but after this time, blood glucose almost according to similar pattern is reduced and in 90 minutes, it will reach its minimal level.
Conclusion: Therefore, it seems that GABA-A receptors have an inhibiting role in regulation of blood glucose. Further research seems inevitable since the effects of GABA-A receptors on blood glucose (concentration is a complex phenomenon.

 
Keyword(s):  BICCUCULINE, GLUCOSE, PICROTOXIN
 
 
References: 
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Citations: 
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APA: Copy

GHIRVANI, Z., & POURGHOLAMI, M. (2003). A COMPARATIVE STUDY OF THE EFFECTS OF INTRAPERITONEAL AND INTRACEREBELLAR VENTRICLE INJECTION OF PICROTOXIN AND BICCUCULINE ON REGULATION OF BLOOD GLUCOSE CONCENTRATION IN MICE. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, 12(46), 7-17. https://www.sid.ir/en/journal/ViewPaper.aspx?id=2850



Vancouver: Copy

GHIRVANI Z., POURGHOLAMI M.H.. A COMPARATIVE STUDY OF THE EFFECTS OF INTRAPERITONEAL AND INTRACEREBELLAR VENTRICLE INJECTION OF PICROTOXIN AND BICCUCULINE ON REGULATION OF BLOOD GLUCOSE CONCENTRATION IN MICE. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES. 2003 [cited 2021June19];12(46):7-17. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=2850



IEEE: Copy

GHIRVANI, Z., POURGHOLAMI, M., 2003. A COMPARATIVE STUDY OF THE EFFECTS OF INTRAPERITONEAL AND INTRACEREBELLAR VENTRICLE INJECTION OF PICROTOXIN AND BICCUCULINE ON REGULATION OF BLOOD GLUCOSE CONCENTRATION IN MICE. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, [online] 12(46), pp.7-17. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=2850.



 
 
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