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Paper Information

Journal:   INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY   SUMMER 2012 , Volume 6 , Number SUPPLEMENT 1; Page(s) 144 To 144.
 
Paper: 

THE ASSOCIATION OF APOPROTIEN E POLYMORPHISMS WITH RECURRENT MISCARRIAGE IN IRANIAN WOMEN

 
 
Author(s):  ASGARI N.*, AKBARI M.T.
 
* DEPARTMENT OF BIOLOGY, FACULTY OF BASIS SCIENCE, ISLAMIC AZAD UNIVERSITY, SCIENCE AND RESEARCH BRANCH, TEHRAN, IRAN
 
Abstract: 
Background: Thrombophilia has been viewed as a multigenic disorder rather than a monogenetic clinical phenotype and Apo E has been shown to play an important role in lipid metabolism in pregnancy. As individuals carrying the E4 allele of the Apo E gene have the highest risk for thrombosis, we evaluated the frequency of the Apo E4 genotype among women suffering from recurrent pregnancy loss.
Materials and Methods: 81 women with a history of two or more consecutive spontaneous abortions were examined for their APO-E genotypes based on restriction fragment length polymorphism analysis of PCR amplified fragments including amino acid positions 112 and 158.
The observed genotypes were compared with negative controls.
Results: Women experiencing recurrent pregnancy loss had a significantly higher prevalence of Apo E3/4, E4/4 genotypes (19.75%) compared with control women (2.46%) (p=0.00001).
Conclusion: Apo E4 polymorphism may contribute to the thrombophilic risk factors contributing to recurrent pregnancy loss.
 
Keyword(s): APO E4 POLYMORPHISM, APOLIPOPROTEIN E, RECURRENT PREGNANCY LOSS
 
References: 
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