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Paper Information

Journal:   INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE   OCTOBER 2012 , Volume 3 , Number 4; Page(s) 166 To 175.
 
Paper: 

ELECTROLYTES DISTURBANCE AND CYCLOSPORINE BLOOD LEVELS AMONG KIDNEY TRANSPLANT RECIPIENTS

 
 
Author(s):  EINOLAHI B., NEMATI E.*, ROSTAMI Z., BARADARAN EFTEKHARI M., GHADIAN A.R.
 
* NEPHROLOGY AND UROLOGY RESEARCH CENTER, BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Background: Kidney transplantation is associated with various biochemical abnormalities such as changes in serum blood level of sodium (Na), potassium (K), calcium (Ca), and phosphorous (P). Although cyclosporine (CsA) is used commonly, the prevalence of its side effects, including electrolytes disturbance, is not well understood.
Objective: To find the prevalence of electrolytes disturbance and its relation to CsA blood levels.
Methods: In a retrospective study, 3308 kidney transplant recipients transplanted between 2008 and 2011 were studied. We evaluated the relation between serum Ca, P, Na, K and CsA trough (C0) and 2-hour post-dose (C2) levels.
Results: The mean
±SD age of recipients was 37±15 years; 63% of patients were male. Overall, C2 levels had correlation with Ca blood level (p=0.018; OR: 1.13, 95% CI: 1.02–1.25), C0 levels had also correlation with blood levels of P and Cr (p<0.001; OR: 1.83, 95% CI: 1.59–2.11).
Conclusion: Electrolyte disturbances are prevalent. Higher serum levels of CsA can worsen the allograft function by disturbing the serum P and Ca levels.

 
Keyword(s): CYCLOSPORINE, KIDNEY, TRANSPLANTATION, ELECTROLYTES
 
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