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Paper Information

Journal:   FINDINGS SCIENCE   2011 , Volume 7 , Number 3; Page(s) 0 To 0.
 
Paper: 

EFFECT OF INTRACEREBROVENTRICULAR PERFUSION OF TESTOSTERONE ENANTHATE ON EXPRESSION MORPHINE –INDUCED CONDITIONED PLACE PREFERENCE IN ADULT MALE RAT.

 
 
Author(s):  HEIDARIEH N.*
 
* 
 
Abstract: 

Tolerance and dependency are two main problems of drug abuse including morphine administration. It has been suggested that many drugs are involved in morphine –induced psychological dependency. The current study was aimed to determine that, whether or not long-term intracerebroventricular (ICV) perfusion of testosterone enanthate could modify the expression of morphine-induced conditioned place preference (CPP) in adult male wistar rat.
Male wistar rats (250-300gr) were anaesthetized with chloral hydrate (500 mg/kg, i.p.). Guide cannula was implanted in the right lateral ventricle using stereotaxic instrument. After one week recovery from surgery, rats subjected to subcutaneous administration of morphine on training days, and long-term ICV perfusion of testosterone enanthate (2
ml/min for 2 hours) using microdialysis probe and guide cannula on testing day. Biased method was used to determine the induction of CPP in rats. Changes were monitored in all groups; and all statistical analysis was carried out using absolute data and one-way ANOVA.
The present results indicated that subcutaneous of different doses of morphine sulfate (0.5-10 mg/kg) produced a significant dose-dependent CPP in all experimental groups. The ICV perfusion of testosterone enanthate (2 mg/kg) did not produce reliable CPP, however, long-term ICV perfusion of testosterone enanthate significantly modified the expression of morphine-induced (10 mg/kg) conditioned place preference.
So, testosterone enanthate increase morphine dependent euphoria and /or reward.

 
Keyword(s): TESTOSTERONE ENANTHATE, MORPHINE, EXPRESSION CONDITIONED PLACE PREFERENCE, PSYCHOLOGICAL DEPENDENCY, MICRODIALYSIS PROBE
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

HEIDARIEH, N. (2011). EFFECT OF INTRACEREBROVENTRICULAR PERFUSION OF TESTOSTERONE ENANTHATE ON EXPRESSION MORPHINE –INDUCED CONDITIONED PLACE PREFERENCE IN ADULT MALE RAT.. FINDINGS SCIENCE, 7(3), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=277470



Vancouver: Copy

HEIDARIEH N.. EFFECT OF INTRACEREBROVENTRICULAR PERFUSION OF TESTOSTERONE ENANTHATE ON EXPRESSION MORPHINE –INDUCED CONDITIONED PLACE PREFERENCE IN ADULT MALE RAT.. FINDINGS SCIENCE. 2011 [cited 2021July30];7(3):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=277470



IEEE: Copy

HEIDARIEH, N., 2011. EFFECT OF INTRACEREBROVENTRICULAR PERFUSION OF TESTOSTERONE ENANTHATE ON EXPRESSION MORPHINE –INDUCED CONDITIONED PLACE PREFERENCE IN ADULT MALE RAT.. FINDINGS SCIENCE, [online] 7(3), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=277470.



 
 
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