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Paper Information

Journal:   FINDINGS SCIENCE   2011 , Volume 7 , Number 3; Page(s) 0 To 0.
 
Paper: 

THE EFFECT OF RALOXIFENC ON KIDNEY IN ONE DAY OLD MICE BALB/C

 
 
Author(s):  HEMAYATKHAH JAHROMI V., FOROZANFAR M., HERZI M., KARGAR H., JOWHARY H.
 
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Abstract: 

Raloxifene is a non-steroidal selective estrogen-receptor modulator. Since raloxifene affects sex hormone of females, it is prescribed only for women. In this study, the effect of raloxifene is investigated on kidney in mice offspring Balb/C race. The research was done on 42 pregnant mice, with average weight of 30 to 36 g and 10 weeks age. The animals were divided in 7 groups, each group 6 mice. Control group received no raloxifene. Treatment groups received 0.005, 0.01, and 0.02 mg/kg of raloxifene. Treatment duration, was both during the last week of pregnancy and during the whole pregnancy period. Babies of mice were born and were sacrificed. The number, weight and length of babies is measured.Then we removed the kidneys of babies, and measured the length and the width of kidneys. Next, we investigated the diameter of glomerulus’s, Bowman’s capsule, distal tubule, proximal tubule and the number of masengial cells. In the study of tissue of experimental groups, necrosis and histological changes weren’t observed. The results, showed that raloxifene is decreased significantly the number of mice babies and their length and weight, but the length and the width of kidneys was significantly increased. Also, the diameter of Bowman’s capsule, glomerulus’s, distal tubule and proximal tubule and the number of masengial cells did not change. So according to these results, we concluded that raloxifene is occurred morphometeric changes and did not affect the structure of kidney tissues.

 
Keyword(s): RALOXIFENE, KIDNEY, PREGNANCY, MICE
 
 
References: 
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APA: Copy

HEMAYATKHAH JAHROMI, V., & FOROZANFAR, M., & HERZI, M., & KARGAR, H., & JOWHARY, H. (2011). THE EFFECT OF RALOXIFENC ON KIDNEY IN ONE DAY OLD MICE BALB/C. FINDINGS SCIENCE, 7(3), 0-0. https://www.sid.ir/en/journal/ViewPaper.aspx?id=277455



Vancouver: Copy

HEMAYATKHAH JAHROMI V., FOROZANFAR M., HERZI M., KARGAR H., JOWHARY H.. THE EFFECT OF RALOXIFENC ON KIDNEY IN ONE DAY OLD MICE BALB/C. FINDINGS SCIENCE. 2011 [cited 2021May17];7(3):0-0. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=277455



IEEE: Copy

HEMAYATKHAH JAHROMI, V., FOROZANFAR, M., HERZI, M., KARGAR, H., JOWHARY, H., 2011. THE EFFECT OF RALOXIFENC ON KIDNEY IN ONE DAY OLD MICE BALB/C. FINDINGS SCIENCE, [online] 7(3), pp.0-0. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=277455.



 
 
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