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Paper Information

Journal:   FINDINGS SCIENCE   2011 , Volume 7 , Number 3; Page(s) 0 To 0.
 
Paper: 

EFFECT OF GREEN TEA EPIGALLOCATECHIN-3-GALLATE (EGCG) ON PASSIVE AVOIDANCE LEARNING IN ADULT MALE WISTAR RATS

 
 
Author(s):  TABAEI A.S., HEIDARIEH N., KAZEMI M.
 
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Abstract: 

Along with increased age, learning and memory being two of the survival necessities decrease and may even deteriorate. This has motivated researches in the field of geriatric medicine to find new medicines effective on learning and memory amplification. Studies have shown that through advanced age, increased oxidative stressors lead to damaged brain processes including cognitive functions. Since green tea epigallocatechin gallate contain antioxidants, this study aimed to examine the effect of this material on passive avoidance learning in adult male wistar rats.
forty two male wistar rats, each weighing about 250-300 g were divided into tree sham group, control group (animals administered with solvent) and experimental group (animals administered with 15, 30, 45 and 60 mg/kg per day of green tea EGCG). All of groups with no limitation had access to water vessel. To prevent modification of ingredients, vessels contents were regularly refreshed. The green tea EGCG or normal saline were administered through intraperitoneally (ip), once daily for two consecutive weeks. The passive avoidance learning test was done in the Shuttle box device following intending treatments for all groups and in similar conditions. In this test, increased time delay for the first time of entry to the dark chamber and decreased remaining time in the dark chamber indicates improved passive avoidance learning. The data were analyzed by spss soft one-way analysis of variance followed by the Tukey test.
Findings: Compared with the intact and control group, passive avoidance learning indices had significantly increased in the test group.
Conclusion: Our results show that administered epigallocatechin gallate causes increased learning and passive avoidance indices in rats; probably the reason was existence of antioxidant, decrease lipid peroxide production and reduce oxidative DNA damage effects of these compounds.

 
Keyword(s): GREEN TEA EPIGALLOCATECHIN GALLATE, PASSIVE AVOIDANCE LEARNING, MEMORY, ADULT MALE WISTAR RATS
 
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