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Paper Information

Journal:   JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS)   JANUARY 2011 , Volume 13 , Number 1 (58); Page(s) 7 To 13.
 
Paper: 

A COMPARISON BETWEEN THE EFFECT OF HALOTHANE AND PROPOFOL ON LIVER ENZYMES AFTER GENERAL ANESTHESIA

 
 
Author(s):  KASHIFARD M.*, ALIJANPOUR E., HOSEINIAN M.
 
* DEPARTMENT OF INTERNAL MEDICINE, AYATOLLAH ROOHANI HOSPITAL, BABOL, IRAN
 
Abstract: 

BACKGROUND AND OBJECTIVE: Halothane is the most common inhalation anesthetic drug in the world and there is an increasing interest for using intravenous anesthetics like propofol. The purpose of this study was to compare the effect of halothane and propofol on hepatic enzymes after general anesthesia.
METHODS: This randomized clinical trial study was performed on 58 patients (14-69 years old) classified in class I of American Society of Anesthetics. These patients who had no preliminary symptomatic hepatic, cardiac or renal disease admitted for elective surgery (ENT, eye, orthopedics, general surgery, and urology). These patients were divided randomly into two groups: 30 patients in the propofol group and 28 patients in the halothane group. In both groups, pre-medication and induction of anesthesia were the same. For the maintenance of anesthesia in the study group there was continuous infusion of propofol and for the control group, 0.5-1% halothane inhalation. From all the patients, three blood samples were taken separately prior to the anesthesia, twenty four hours and seven days after the anesthesia. These samples were tested and compared for aspartate aminotransferase (AST), alanine amino transferase (ALT), alkaline phosphates (ALP) and Billirubin (total and direct)
FINDINGS: Mean anesthesia duration in propofol group was 91
±14.7 minute and in halothan group was 93.2±17 minute that there was not statistically significant difference in duration of anesthesia between the two groups. Seven days after anesthesia ALP, the total and direct billirubine levels did not show significant differences between the two groups. However, AST (p=0.008) and ALT (p=0.003) increased in halothane group in compared with propofol group.
CONCLUSION: The results show that propofol has less effect on liver enzymes as compared to halothane. This can be considered in anesthetic drug usage.

 
Keyword(s): HALOTHANE, PROPOFOL, LIVER ENZYMES, GENERAL ANESTHESIA
 
 
References: 
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Click to Cite.
APA: Copy

KASHIFARD, M., & ALIJANPOUR, E., & HOSEINIAN, M. (2011). A COMPARISON BETWEEN THE EFFECT OF HALOTHANE AND PROPOFOL ON LIVER ENZYMES AFTER GENERAL ANESTHESIA. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), 13(1 (58)), 7-13. https://www.sid.ir/en/journal/ViewPaper.aspx?id=277374



Vancouver: Copy

KASHIFARD M., ALIJANPOUR E., HOSEINIAN M.. A COMPARISON BETWEEN THE EFFECT OF HALOTHANE AND PROPOFOL ON LIVER ENZYMES AFTER GENERAL ANESTHESIA. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS). 2011 [cited 2021May06];13(1 (58)):7-13. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=277374



IEEE: Copy

KASHIFARD, M., ALIJANPOUR, E., HOSEINIAN, M., 2011. A COMPARISON BETWEEN THE EFFECT OF HALOTHANE AND PROPOFOL ON LIVER ENZYMES AFTER GENERAL ANESTHESIA. JOURNAL OF BABOL UNIVERSITY OF MEDICAL SCIENCES (JBUMS), [online] 13(1 (58)), pp.7-13. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=277374.



 
 
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