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Paper Information

Journal:   JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   DECEMBER 2011 , Volume 21 , Number 85; Page(s) 92 To 98.
 
Paper: 

HISTOMETRIC AND HISTOPATHOLOGIC STUDY OF SOYBEAN HYDROALCOHOLIC EXTRACT ON TESTICULAR TISSUE AND PITUITARY-GONAD AXIS IN ADULT MALE RAT

 
 
Author(s):  AHSANNIA NEHLEH, ZAHIRI SHAHLA, MAHJOUR AMIR ASHKAN, TAVASOLI ALIREZA, SAFARPOUR DANIAL
 
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Abstract: 

Background and purpose: Studies have indicated that phytoestrogens in soybean can influence the reproductive system. The aim of this study was to investigate the effect of hydroalcoholic extract of soybean on testicular tissue and pituitary-gonad axis in male rat.
Materials and methods: Forty adult male Wistar rats were randomly allocated into five groups including control, sham, and three experimental. Animals in the experimental groups received soybean extract for 48 days at doses of 30, 60, and 120 mg/kg by gavage, respectively. The rats in the sham group received only water by gavage for the same period, as well. In the control group received no treatment. Animals’ weight was measured before and after the intervention. After that, the animals were anesthetized and the levels of LH, FSH, and testosterone hormones were measured by collecting blood from their hearts. In the end, the left and right testes were removed and weighed. Quantitative and qualitative studies were done on the left testis of each rat.
Results: Administration of soybean hydroalcoholic extract at doses of 30, 60, and 120 mg/kg did not have any negative effect on body weight, gonads, testicular function, and histometric parameters. Administration of extract with the highest dose used in this study (120 mg/kg) significantly decreased the plasma LH level, germinal epithelium length, and repopulation index (P<0.05). Furthermore, histopathologic studies did not show any damage on testicular tissue.
Conclusion: The results indicated that soybean in routine doses that used in this study did not exert considerable negative effects on testicular tissue and hormone secretion in the rats.

 
Keyword(s): SOYBEAN, TESTICULAR TISSUE, HISTOMETRY, HISTOPATHOLOGY, RAT
 
 
References: 
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APA: Copy

AHSANNIA, N., & ZAHIRI, S., & MAHJOUR, A., & TAVASOLI, A., & SAFARPOUR, D. (2011). HISTOMETRIC AND HISTOPATHOLOGIC STUDY OF SOYBEAN HYDROALCOHOLIC EXTRACT ON TESTICULAR TISSUE AND PITUITARY-GONAD AXIS IN ADULT MALE RAT. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 21(85), 92-98. https://www.sid.ir/en/journal/ViewPaper.aspx?id=277208



Vancouver: Copy

AHSANNIA NEHLEH, ZAHIRI SHAHLA, MAHJOUR AMIR ASHKAN, TAVASOLI ALIREZA, SAFARPOUR DANIAL. HISTOMETRIC AND HISTOPATHOLOGIC STUDY OF SOYBEAN HYDROALCOHOLIC EXTRACT ON TESTICULAR TISSUE AND PITUITARY-GONAD AXIS IN ADULT MALE RAT. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES. 2011 [cited 2021July31];21(85):92-98. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=277208



IEEE: Copy

AHSANNIA, N., ZAHIRI, S., MAHJOUR, A., TAVASOLI, A., SAFARPOUR, D., 2011. HISTOMETRIC AND HISTOPATHOLOGIC STUDY OF SOYBEAN HYDROALCOHOLIC EXTRACT ON TESTICULAR TISSUE AND PITUITARY-GONAD AXIS IN ADULT MALE RAT. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, [online] 21(85), pp.92-98. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=277208.



 
 
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