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Paper Information

Journal:   FINDINGS SCIENCE   SPRING 2012 , Volume 8 , Number 1; Page(s) 0 To 0.
 
Paper: 

A COMPARATIVE STUDY ON THE ANTICONVULSIVE EFFECT OF THE HYDROALCHOLIC EXTRACT OF THE MELISSA OFFICINALIS PLANT WITH PHENYTOIN ON WISTAR RAT

 
 
Author(s):  GORGIJ E.*, KOMEILI GH.R., ZAKERI Z., EBRAHIMI S.
 
* 
 
Abstract: 

Epilepsy in is one of the most common neurological disorders in humans and Melissa officinalis (Lemon balm) can be used to treat epilepsy. So in this exprimental word, the effect of pretreatment with Hydroalcoholic extract of this plant and comparing it with Phenytoin in oreventing siezures of Epilepsy were studied.
in this study, six groups of 8 male adult rats in Wister race and weight range of were used. Before injection, the animals were put in Lp PTZ (90mg/kg) to induce seizures, and then under intraperitoneal injection of (25, 50, 100, 200) mg/kg doses of hydroalcoholic extract of Melissa officinalis (Lemon balm), the positive control drug of choice phenytoin 5 mg/kg and control group of 0.5 ml sterile saline. In order to create epilepsy the facctors were evaluated. The ANOVA test and Tukey test were used in order to compare the mean time of occurrence of different stages.
the injection of extract doses (50, 100, 200) mg/kg increased the onset time of clonic attacks (P<0.001), increase in onset time of tonic attacks (P<0.001) and reduction in numbers of clonic attacks than negative control group and the extarct 100 mg/kg compared with positive control group, delayed the onset time of clonic attacks (P<0.005) and onset time of tonic attacks (P<0.005) more. Furthuremore, The injection of this dose of extract, reduced the duration of tonic attacks (P<0.006) than negative control group. Conclusion: the results of this study show that the prescription of Hydroalcoholic extract of Melissa officinalis (Lemon balm) half hour before induction of seizures, reduce seizure symptoms caused by the injection of PTZ.

 
Keyword(s): MELISSA OFFICINALIS, SEIZURE, PENTYLENE TETRAZOLE, PHENYTOIN, RAT
 
References: 
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