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Paper Information

Journal:   FINDINGS SCIENCE   SPRING 2012 , Volume 8 , Number 1; Page(s) 0 To 0.
 
Paper: 

DIAZINON EFFECT ON THE LIVER ENZYMES OF MALE IRANIAN FROG RANA RIDIBUNDA

 
 
Author(s):  NASRI SIMA, MOHAJERANI H.R., GHASEM ZADEH L.*
 
* 
 
Abstract: 

Diazinon is the one of organophosphate insecticides that is used extensively for agricultural activities, and recognized as an environmental pollutant in the world. This research was done for study of the diazinon effect on blood level of hepatic enzymes. After survival and Lethal dose test of diazionon, 72 male Rana ridibunda with weight range of 100 to 150 gram were collected from Anzali wetland and divided to 9 groups (n=8 in each group) contain of control group that were exposed to water without diazinon and 8 treatment groups that were exposed to 30, 60, 90 and 120 µgram/liter diazinon and for each concentration, two period of time respected: One day and one week after diazinon exposure. Then blood samples prepared from frogs and centrifuged with 2500 rpm for 10 minutes and serum isolated for photometric measuring of alkaline phosphatase (DGKC method) and aspartate aminotransferase and alanin aminotransferase (IFCC method). Results indicated those ALP enzymes were increased significantly by 30, 60, 90 and 120µgram/liter of diazinon at 24 hours and one week after treatment. For ALT and AST this difference was significant for 60, 90 and 120 µgram/liter in one week time period (P<.05).Rising of hepatic enzymes probably show that hepatocytes were injured and then regenerated.
Results of this study demonstrated the increasing effect of diazinon on blood level of hepatic enzymes and detoxification response of liver in basis of acute model of diazinon intoxication.

 
Keyword(s): DIAZINON, RANA RIDIBUNDA, AST, ALT, ALP
 
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