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Paper Information

Journal:   BINA   WINTER 2013 , Volume 18 , Number 2 (71); Page(s) 147 To 155.
 
Paper: 

GABAPENTIN VERSUS PREGABALIN FOR POSTOPERATIVE PAIN: A RANDOMIZED PLACEBO-CONTROLLED TRIAL

 
 
Author(s):  PAKRAVAN M.*, ROSHANI M., ABBASNIA E., YAZDANI S., FARAMARZI A., YASERI M.
 
* OPHTHALMIC RESEARCH CENTER, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Purpose: To evaluate the efficacy of pregabalin and gabapentin for post-photorefractive keratectomy (PRK) pain relief.
Methods: 150 patients were divided into 3 groups. After undergoing PRK; groups 1, 2, 3 received pregabalin 75 mg, gabapentin 300 mg, and placebo 3 times daily for 3 days, respectively. Patients could take acetaminophen-codeine 300/10 mg tablets every 4 hours as needed. Patients completed a pain assessment survey (visual analogue scale ranging from 0=no pain to 10=most severe pain) 7 times in the first 3 days following PRK and also recorded the number of consumed acetaminophen-codeine tablets.
Results: The three groups were similar in terms of age, sex, refractive error, ablation depth, and mitomycin- C (MMC) application (all p values>0.05). Overall, pain score in the placebo group was higher than the pregabalin (P=0.029) and gabapentin (P=0.023) groups, respectively. Severe pain (score>7) was more frequent in the placebo group on the morning of the first postoperative day (P=0.043). The number of consumed acetaminophen-codeine tablets was lower in the pregabalin and gabapentin groups than the placebo group, but this difference didn't reach statistical significance (P=0.061).
Conclusion: Pregabalin and gabapentin are helpful in alleviating post-PRK pain when combined with other medications. Depending on availability, either compound can be used as an adjuvant for pain control in this setting.

 
Keyword(s): GABAPENTIN, PREGABALIN, PHOTOREFRACTIVE KERATECTOMY, POSTOPERATIVE PAIN
 
 
References: 
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Citations: 
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APA: Copy

PAKRAVAN, M., & ROSHANI, M., & ABBASNIA, E., & YAZDANI, S., & FARAMARZI, A., & YASERI, M. (2013). GABAPENTIN VERSUS PREGABALIN FOR POSTOPERATIVE PAIN: A RANDOMIZED PLACEBO-CONTROLLED TRIAL. BINA, 18(2 (71)), 147-155. https://www.sid.ir/en/journal/ViewPaper.aspx?id=277065



Vancouver: Copy

PAKRAVAN M., ROSHANI M., ABBASNIA E., YAZDANI S., FARAMARZI A., YASERI M.. GABAPENTIN VERSUS PREGABALIN FOR POSTOPERATIVE PAIN: A RANDOMIZED PLACEBO-CONTROLLED TRIAL. BINA. 2013 [cited 2021August06];18(2 (71)):147-155. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=277065



IEEE: Copy

PAKRAVAN, M., ROSHANI, M., ABBASNIA, E., YAZDANI, S., FARAMARZI, A., YASERI, M., 2013. GABAPENTIN VERSUS PREGABALIN FOR POSTOPERATIVE PAIN: A RANDOMIZED PLACEBO-CONTROLLED TRIAL. BINA, [online] 18(2 (71)), pp.147-155. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=277065.



 
 
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