Paper Information

Journal:   JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES   WINTER 2012 , Volume 10 , Number 4 (41); Page(s) 267 To 278.
 
Paper: 

INVESTIGATION ON GENE-ENVIRONMENT INTERACTION USING BREAST CANCER DATA; A CASE-ONLY AND CASE-CONTROL DESIGNS

 
 
Author(s):  MORADZADEH R.*, HASANZADEH J., RAJAAEIFARD A.R., TAHMASEBI S., GOLMOHAMMADI P.
 
* DEPT. OF EPIDEMIOLOGY, SCHOOL OF NURSING AND MIDWIFERY, ISLAMIC AZAD UNIVERSITY, SANANDAJ BRANCH, SANANDAJ, IRAN
 
Abstract: 

Background and Objectives: The role of gene-environment interaction in epidemiology has been widely considered. The traditional methods of studying the gene-environment interaction need appropriate control groups which their selection may be associated with some problems. Therefore, new methods have been created to study these interactions from which are the case-only designs. In this method, only the cases data are being used. In this study, gene-environment interaction in patients with breast cancer was investigated using the case-only and case-control designs.
Material and Methods: This study conducted in 2008, using two methods: matched case-control and case-only. Simple random sampling was used to select 300 patients with breast cancer in Shahid Mottahari Clinic for two aforementhioned designs. The control group for the matched case-control study was selected from the women referring to Shahid Mottahari Clinic. Data were analysed using lagistic regressian and conditional logistic regression.
Results: The confidence intervals and log likelihood in all variables in case-only design was better than the matched case-control. In case-only design, the standard error in the following variables; age at menarche, the first delivery at the age of
³34yrs and/or nulliparity, the number of live births, use of oral contraception pills, and breastfeeding history were less than those in the matched case-control design. In case-only design, the P-value of the above-menthined variables was less than those of the matched case-control design.
Conclusion: The case-only design is an efficiency method for investigating of the interaction in terms of statistical study, sample size and the easily implementing.

 
Keyword(s): CASE-ONLY, CASE-CONTROL, BREAST CANCER, GENE-ENVIRONMENT INTERACTION
 
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