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Paper Information

Journal:   JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES   WINTER 2012 , Volume 10 , Number 4 (41); Page(s) 245 To 254.
 
Paper: 

EFFECTS OF AVICENNIA MARINA LEAVES AQUEOUS AND HYDRO ALCOHOLIC EXTRACT ON STREPTOZOTOCIN-INDUCED DIABETIC MALE RATS

 
 
Author(s):  FATHI MOGHADDAM H., MOKHTARI M., KAMAEI L., AHANGARPOUR A.*
 
* DEPT. OF PHYSIOLOGY, DIABETE RESEARCH CENTER AND PHYSIOLOGY RESEARCH CENTER PERSIAN GULF, AHWAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES, AHVAZ, IRAN
 
Abstract: 

Background and Objectives: Diabetes Mellitus is a major endocrine disorder and growing health problem in most of countries. Avicennia marina is a type of mangrove plants which can grows in the Iranian coastal areas of Persian Gulf. We studied the effects of Avicennia marina leaves aqueous and hydroalcoholic extract on streptozotocin -induced diabetic male rats.
Material and Methods: In this experimental study, 45 male rats were randomly divided into nine groups of five. Control animals were fed with a normal diet. The test groups received intraperitoneal injection of 60 mg/kg streptozotocin for induction of diabetes. The diabetic groups were further subgrouped into; diabetes, diabetic control (given 0.9% normal saline) and 6 groups treated orally with aqueous and hydroalcoholic extract of Avicennia marina leaves (30, 60, 120 mg/kg daily for three consecutive days). Twenty-four hours after the last treatment, blood samples were collected from heart for determining the blood glucose and insulin concentration levels using glucose oxidase and enzyme-linked immunosorbent assay (ELISA) methods respectively.
Results: Our results indicated that aqueous and hydroalcoholic extracts of Avicennia marina leaves could decrease the mean blood glucose of diabetic test rats compared to diabetic control group (from 293.8
±10.88 to 131.4±2.97 vs 139±1.92 respectively). Also, a significant increase in the serum insulin levels with no increase in the final body weights was found in the former group. No toxic effects of leaves extract was observed after 2 days of treatment.
Conclusions: In this study, we have shown that Avicennia marina leaves extract can significantly decrease the blood glucose level.

 
Keyword(s): AVICENNIA MARINA, DIABETE, BLOOD GLUCOSE, INSULIN
 
References: 
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