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Paper Information

Journal:   IRANIAN HEART JOURNAL (IHJ)   SUMMER 2011 , Volume 12 , Number 2; Page(s) 34 To 40.
 
Paper: 

ASSOCIATION BETWEEN PERIODONTAL PATHOGENS AND CORONARY ARTERY DISEASE: A CASE-CONTROL STUDY

 
 
Author(s):  TALEBI ARDAKANI MOHAMMAD REZA, SOBOTI FARHAD, ALIZADEH GHAVIDEL ALIREZA, GHOLAMPOUR DEHAKI MAZIAR, SHARIATI MAHSA, KAZEMI BAHRAM
 
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Abstract: 

Background and Aim-We sought to answer the questions about the role of inflammatory factors in the formation of pathological lesions in the endothelium of the coronary vessels and also the role of host based bacteria, including chronic periodontitis, in the clot formation in the blood vessels, all of which destabilize the atherosclerotic plaque.
Methods and Materials-This case-control study was done on 40 patients who underwent elective coronary artery bypass grafting surgery (CABG) with the need of coronary endarterectomy. In Group A, patients had chronic periodontitis and group B consisted of patients without it. Both groups were well matched regarding their demographic data. The subgingival plaque was collected by a sterile curette from periodontal pockets 5mm and CAL 4mm. Also, atherosclerotic plaque was collected during the coronary endarterectomy surgery from all of the 40 patients. The specimens were assessed using the PCR technique to detect the specific bacteria responsible for chronic periodontitis such as actinobacillus actinomycetemcomitans (Aa), prevotella intermedia (Pi), porphyromonas gingivalis (Pg), Tanerella forsythensis (Tf), Treponema denticola (Td), and fusobacterium nucleatum (Fn).
Results-In the atherosclerotic plaque of group A patients, Aa was identified in 18 (90%), Pg in 16 (80%), Tf in 13 (65%), Td in 11 (55%), Pi in 10 (50%), and Fn in 6 (30%) specimens, whereas in group B the incidence was significantly lower (p<0.0001). In the subgingival plaque of group A, Aa and Tf were found in all 20 individuals and Pg, Pi, Td and Fn were identified in 19 specimens (95%). The differences in the incidence of Aa and Pg in two plaque samples were not significant, but the two plaque samples showed significant differences regarding the incidence of the other pathogens (Pi: p<0.001, Tf: p<0.008, Td: p<0.003 and Fn: p<0.0001).
Conclusion-In the present study, the same organisms were found in both coronary atherosclerotic and subgingival plaques. The findings support the potential role of the periodontopathogenic bacteria species in some steps of the atherosclerotic process as a contributor that worsens this disease.
However, further studies are required to achieve more definite results regarding the role of periodontal diseases in the atherosclerotic disease, focusing on patients' background variables.

 
Keyword(s): ATHEROSCLEROSIS, CORONARY ARTERY DISEASE, CHRONIC PERIODONTITIS
 
 
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APA: Copy

TALEBI ARDAKANI, M., & SOBOTI, F., & ALIZADEH GHAVIDEL, A., & GHOLAMPOUR DEHAKI, M., & SHARIATI, M., & KAZEMI, B. (2011). ASSOCIATION BETWEEN PERIODONTAL PATHOGENS AND CORONARY ARTERY DISEASE: A CASE-CONTROL STUDY. IRANIAN HEART JOURNAL (IHJ), 12(2), 34-40. https://www.sid.ir/en/journal/ViewPaper.aspx?id=276604



Vancouver: Copy

TALEBI ARDAKANI MOHAMMAD REZA, SOBOTI FARHAD, ALIZADEH GHAVIDEL ALIREZA, GHOLAMPOUR DEHAKI MAZIAR, SHARIATI MAHSA, KAZEMI BAHRAM. ASSOCIATION BETWEEN PERIODONTAL PATHOGENS AND CORONARY ARTERY DISEASE: A CASE-CONTROL STUDY. IRANIAN HEART JOURNAL (IHJ). 2011 [cited 2021July29];12(2):34-40. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=276604



IEEE: Copy

TALEBI ARDAKANI, M., SOBOTI, F., ALIZADEH GHAVIDEL, A., GHOLAMPOUR DEHAKI, M., SHARIATI, M., KAZEMI, B., 2011. ASSOCIATION BETWEEN PERIODONTAL PATHOGENS AND CORONARY ARTERY DISEASE: A CASE-CONTROL STUDY. IRANIAN HEART JOURNAL (IHJ), [online] 12(2), pp.34-40. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=276604.



 
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