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Paper Information

Journal:   DERMATOLOGY AND COSMETIC   FALL 2010 , Volume 1 , Number 3; Page(s) 112 To 118.
 
Paper: 

ASSESMENT OF ANGIOGENESIS IN BASAL CELL CARCINOMA USING CD31 & CD34 MARKERS AND RELATION WITH TUMOR INVASIVENESS IN HISTOLOGY

 
 
Author(s):  SAFAEI NARAGHI ZAHRA*, HADISI MAHDI, AMANI FIROUZ, FATHI SOULMAZ
 
* DEPARTMENT OF PATHOLOGY, RAZI HOSPITAL, TEHRAN, IRAN
 
Abstract: 
Background and Aim: Tumor angiogenesis is essential for tumor growth and appears to play an importating role both in invasive growth and metastasis.
Basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) of the skin are derived from a similar cell type but differ in the invasive and metastatic potential. Basal cell carcinoma generally shows a relatively benign course in contrast to squamous cell carcinoma. This study investigates whether the behavior of these tumors could be explained by differences in their angiogenesis pattern.
Material and Methods: Vessel counts were made of blood vessels in stroma and the body of 50 variants of BCC of skin samples including: nodular, micro nodular, sclerosing and superficial, both after H& E and immunohistochemical staining for CD31 and CD34 markers.
Results: The body vessel counts of invasive variants (sclerosing & micro nodular) differed significantly from the counts of noninvasive variants (nodular and superficial) using both CD31 & CD34 markers. The stromal vessel counts compared between invasive and noninvasive variants showed no significantly difference using CD31 & CD34 markers, respectively.
Discussion: The invasive growth pattern of BCC variants correlated with the micro vascular density and according to results, vessel counts of the body play a more important role.
 
Keyword(s): ANGIOGENESIS, BASAL CELL CARCINOMA, INVASION, METASTASIS, MVD
 
 
References: 
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Citations: 
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APA: Copy

SAFAEI NARAGHI, Z., & HADISI, M., & AMANI, F., & FATHI, S. (2010). ASSESMENT OF ANGIOGENESIS IN BASAL CELL CARCINOMA USING CD31 & CD34 MARKERS AND RELATION WITH TUMOR INVASIVENESS IN HISTOLOGY. DERMATOLOGY AND COSMETIC, 1(3), 112-118. https://www.sid.ir/en/journal/ViewPaper.aspx?id=276594



Vancouver: Copy

SAFAEI NARAGHI ZAHRA, HADISI MAHDI, AMANI FIROUZ, FATHI SOULMAZ. ASSESMENT OF ANGIOGENESIS IN BASAL CELL CARCINOMA USING CD31 & CD34 MARKERS AND RELATION WITH TUMOR INVASIVENESS IN HISTOLOGY. DERMATOLOGY AND COSMETIC. 2010 [cited 2021August02];1(3):112-118. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=276594



IEEE: Copy

SAFAEI NARAGHI, Z., HADISI, M., AMANI, F., FATHI, S., 2010. ASSESMENT OF ANGIOGENESIS IN BASAL CELL CARCINOMA USING CD31 & CD34 MARKERS AND RELATION WITH TUMOR INVASIVENESS IN HISTOLOGY. DERMATOLOGY AND COSMETIC, [online] 1(3), pp.112-118. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=276594.



 
 
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