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Paper Information

Journal:   JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES)   WINTER 2013 , Volume 16 , Number 4 (65); Page(s) 4 To 11.
 
Paper: 

EFFECT OF INTERMITTENT NORMOBARIC HYPEROXIA ON BLOOD BRAIN BARRIER IN A RAT MODEL OF STROKE

 
 
Author(s):  ASHEGHABADI M., BIGDELI M.R.*
 
* FACULTY OF BIOLOGICAL SCIENCES, SHAHID BEHESHTI UNIVERSITY, EVIN, TEHRAN, IRAN
 
Abstract: 

Background: Recent studies have shown that the use of prolonged or intermittent normobaric hyperoxia (90 percent) can decrease brain damages caused by stroke.
Objective: The aim of this study was to investigate the effects of oxygen radicals in potentiating the blood brain barrier caused by normobaric hyperoxia in a rat model of stroke.
Methods: This was a experimental study performed in spring 2010. A total of 42 male Wistar rats (250-350 g) were initially divided into two main groups. Both group were exposed to normobaric hyperoxia (90 percent; HO) and room air (21 percent; RA) 4 h/day for 6 days. Later, each main group was subdivided into three subgroups to receive dimethyltiourea. After 24 h, the neurologic deficit scores and blood brain barrier permeability were assessed. Data were analyzed by one way ANOVA and Mann Whitney U tests.
Findings: The medians of neurologic deficit scores and blood brain barrier permeability decreased in RA and HO (P=0.02). The neurologic deficit score and the reduced brain edema were significantly relived by MT (P=0.43).
Conclusion: The blood brain impermeability caused by intermittent normobaric hyperoxia was relieved by use of oxygen radical scavengers.

 
Keyword(s): NEUROPROTECTION, STROKE, NORMOBARIC HYPEROXIA, NEUROLOGIC DEFICIT, FREE OXYGEN RADICALS
 
 
References: 
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Citations: 
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APA: Copy

ASHEGHABADI, M., & BIGDELI, M. (2013). EFFECT OF INTERMITTENT NORMOBARIC HYPEROXIA ON BLOOD BRAIN BARRIER IN A RAT MODEL OF STROKE. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), 16(4 (65)), 4-11. https://www.sid.ir/en/journal/ViewPaper.aspx?id=276515



Vancouver: Copy

ASHEGHABADI M., BIGDELI M.R.. EFFECT OF INTERMITTENT NORMOBARIC HYPEROXIA ON BLOOD BRAIN BARRIER IN A RAT MODEL OF STROKE. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES). 2013 [cited 2021August01];16(4 (65)):4-11. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=276515



IEEE: Copy

ASHEGHABADI, M., BIGDELI, M., 2013. EFFECT OF INTERMITTENT NORMOBARIC HYPEROXIA ON BLOOD BRAIN BARRIER IN A RAT MODEL OF STROKE. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), [online] 16(4 (65)), pp.4-11. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=276515.



 
 
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