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Paper Information

Journal:   INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY   OCTOBER-DECEMBER 2012 , Volume 6 , Number 3; Page(s) 189 To 194.
 
Paper: 

FERTILITY OUTCOME AFTER TREATMENT OF UNRUPTURED ECTOPIC PREGNANCY WITH TWO DIFFERENT METHOTREXATE PROTOCOLS

 
 
Author(s):  TABATABAII BAFGHI AFSAR, ZARETEZERJANI FATEMAH*, SEKHAVAT LEILA, DEHGHANI FIROUZABADI RAZIAH, RAMAZANKHANI ZEYNAB
 
* DEPARTMENT OF OBSTETRICS AND GYNECOLOGY, SHAHID SADOUGHI HOSPITAL, SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, YAZD, IRAN
 
Abstract: 
Background: The purpose of this study was to compare the success rates of 70 patients from the same database, each with an ectopic pregnancy (EP) that was treated with either the single- or multi-dose methotrexate (MTX) protocols for unruptured EPs.
Materials and Methods: This study was a blinded, randomized clinical trial. Treatment protocols were either single- (50 mg/m2) dose MTX or multi-dose (1 mg/kg MTX+0.1 mg/kg folinic acid).
There were 35 cases in each group. The outcome was measured by adverse events, resolution of pregnancy without surgical treatment, success rate of MTX treatment, and fertility outcome in each group.
Results: With the single-dose protocol, response to treatment was considered successful in 29 (82.9%) patients; in the multi-dose protocol 31 (88.6%) responded to treatment. The difference between success rates in the groups was not statistically significant (p=0.587). In the single dose group, 2 (5.7%) patients and in the multi-dose group, 6 (17.2%) patients had complications (p=0.28). Of the 14 patients in the single-dose group. Clinical pregnancy occurred in 9 (75%) whereas clinical pregnancy occurred in 3 (25%) patients from the multi-dose group. Infertility was seen in 4 (33.3%) patients in the single-dose group and in 8 (66.7%) in the multi-dose group.
Conclusion: We believe that the single-dose MTX protocol could be as successful as multi-dose MTX for the treatment of EP. It is effective, cost-effective, and associated with better fertility outcomes than the multi-dose MTX protocol (Registration Number: IRCT201112178435N1).
 
Keyword(s): ECTOPIC PREGNANCY, METHOTREXATE, PRAGNACY OUTCOME, COMPLICATION
 
 
References: 
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Citations: 
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APA: Copy

TABATABAII BAFGHI, A., & ZARETEZERJANI, F., & SEKHAVAT, L., & DEHGHANI FIROUZABADI, R., & RAMAZANKHANI, Z. (2012). FERTILITY OUTCOME AFTER TREATMENT OF UNRUPTURED ECTOPIC PREGNANCY WITH TWO DIFFERENT METHOTREXATE PROTOCOLS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 6(3), 189-194. https://www.sid.ir/en/journal/ViewPaper.aspx?id=276393



Vancouver: Copy

TABATABAII BAFGHI AFSAR, ZARETEZERJANI FATEMAH, SEKHAVAT LEILA, DEHGHANI FIROUZABADI RAZIAH, RAMAZANKHANI ZEYNAB. FERTILITY OUTCOME AFTER TREATMENT OF UNRUPTURED ECTOPIC PREGNANCY WITH TWO DIFFERENT METHOTREXATE PROTOCOLS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY. 2012 [cited 2021July30];6(3):189-194. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=276393



IEEE: Copy

TABATABAII BAFGHI, A., ZARETEZERJANI, F., SEKHAVAT, L., DEHGHANI FIROUZABADI, R., RAMAZANKHANI, Z., 2012. FERTILITY OUTCOME AFTER TREATMENT OF UNRUPTURED ECTOPIC PREGNANCY WITH TWO DIFFERENT METHOTREXATE PROTOCOLS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, [online] 6(3), pp.189-194. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=276393.



 
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