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Paper Information

Journal:   RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)   SUMMER 2003 , Volume 10 , Number 34; Page(s) 195 To 202.
 
Paper: 

THE ROLE OF ATP SENSITIVE K+ CHANNELS (KATP) ON ISCHEMIA REPERFUSION INDUCED RENAL INJURY IN RATS

 
 
Author(s):  HESAMI ALI, ASGARI MOZHGAN, HOMAYOUNFAR HOMAYOUN, PAZOUKI TOROUDI H.R.*
 
* IRAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, TEHRAN, IRAN
 
Abstract: 

The precise mechanism of ischemia reperfustion (IR) injury is not fully understood. Recent studies on Rat myocardium revealed that activation f the K ATP channels inhibits this process. The goal of this study is coding the same effect of K ATP channels on IR injury, in rat kidney. In his study the effects of K ATP agonist (Diazoxide) and K ATP antagonist (Glibenclamide) plus a K ATP indepennt vasodilator (Hydralazin) on ischemia reperfusion injury examined. Female rats of 200-250g were anesthesized and used for study. Different doses of Diazoxide (1, 5, 15 mg/kg) and Glibenclamid (1, 510 mg/kg) and Hydralazin (1, 3, 15 mg/kg) were used (SC) 120 munutes prior to the initiation of IR. Kidneys were removed and checked histologically for the grading of inury. Diazoxide (5 mg/kg) prevented these lesions. Different doses of Glibenclamide and Hydralazine failed to prevent IR injury. Diazoxide is also a vasodilator agent but failure of Hydralazine to prevent the injury revealed that vasodilation was not the exact mechanism of action of Diazoxide.

 
Keyword(s):  RENAL ISCHEMIA, REPERFUSION (IR), KATP CHANNELS, HYDRALAZINE
 
References: 
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