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Paper Information

Journal:   BASIC AND CLINICAL NEUROSCIENCE   FALL 2011 , Volume 3 , Number 1; Page(s) 48 To 57.
 
Paper: 

VARENICLINE AMELIORATES LEARNING AND MEMORY DEFICITS IN AMYLOID β (25–35) RAT MODEL OF ALZHEIMER’S DISEASE

 
 
Author(s):  BALUCHNEJADMOJARAD TOURANDOKHT*, ROGHANI MEHRDAD, KARIMI NARGES, KAMRAN MITRA
 
* DEPARTMENT OF PHYSIOLOGY, SCHOOL OF MEDICINE, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Introduction: Alzheimer’s disease (AD) is a enfeeble neurodegenerative disorder characterized by increased b-amyloid (Ab) deposition and neuronal dysfunction leading to impaired learning and recall. Among proposed risk factors, impaired cholinergic transmission is a main cause for incidence of disease.
Methods: In the present study, effects of the intracerebroventricularly administration of an agonist of nicotinic cholinergic receptors, varenicline (0.5 and 2
mg/ml), on learning and memory impairments induced by intrahippocampal Ab (25–35) injection was assessed in rats.
Results: The results showed that the intrahippocampal A
b (25–35) injected rats exhibit lower spontaneous alternation score inY-maze tasks (p<0.05), impaired retention and recall capability in the passive avoidance test (p<0.05), and fewer correct choices (p<0.001) and more errors (p<0.001) in the RAM task. Varenicline, almost in both doses, significantly improved alternation score in Y-maze task (p<0.001), impaired retention and recall capability in the passive avoidance test (p<0.05), and correct choices in the RAM task (p<0.001).
Discussion: This study indicates that varenicline pretreatment attenuates Ab-induced impairment of short-term spatial memory in rats probably due to its agonist activity at nicotinic receptors.

 
Keyword(s): Aβ (25–35), VARENICLINE, PASSIVE AVOIDANCE, Y MAZE, RADIAL MAZE, RAT
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

BALUCHNEJADMOJARAD, T., & ROGHANI, M., & KARIMI, N., & KAMRAN, M. (2011). VARENICLINE AMELIORATES LEARNING AND MEMORY DEFICITS IN AMYLOID β (25–35) RAT MODEL OF ALZHEIMER’S DISEASE. BASIC AND CLINICAL NEUROSCIENCE, 3(1), 48-57. https://www.sid.ir/en/journal/ViewPaper.aspx?id=276296



Vancouver: Copy

BALUCHNEJADMOJARAD TOURANDOKHT, ROGHANI MEHRDAD, KARIMI NARGES, KAMRAN MITRA. VARENICLINE AMELIORATES LEARNING AND MEMORY DEFICITS IN AMYLOID β (25–35) RAT MODEL OF ALZHEIMER’S DISEASE. BASIC AND CLINICAL NEUROSCIENCE. 2011 [cited 2021September25];3(1):48-57. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=276296



IEEE: Copy

BALUCHNEJADMOJARAD, T., ROGHANI, M., KARIMI, N., KAMRAN, M., 2011. VARENICLINE AMELIORATES LEARNING AND MEMORY DEFICITS IN AMYLOID β (25–35) RAT MODEL OF ALZHEIMER’S DISEASE. BASIC AND CLINICAL NEUROSCIENCE, [online] 3(1), pp.48-57. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=276296.



 
 
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