Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   BASIC AND CLINICAL NEUROSCIENCE   FALL 2011 , Volume 3 , Number 1; Page(s) 44 To 47.
 
Paper: 

PROTECTIVE EFFECTS OF N-ACETYL-L-CYSTEIN ON 3, 4-METHYLENE DIOXYMETHAMPHETAMIE-INDUCED NEUROTOXICITY IN CEREBELLUM OF MALE RATS

 
 
Author(s):  SOLEIMANI ASL SARA, FALAHATI PEIMAN, SHEKARRIZ NIMA, MOLAVI NIMA, ESMAEILI FARZANEH, AZIMI ZAHRA, SAJADI FREIDOON, HAYAT PARISA, SAMZADEH KERMANI ALIREZA, MEHDIZADEH MEHDI*
 
* CELLULAR AND MOLECULAR RESEARCH CENTER, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Introduction: 3-4, methylenedioxymethamphetamine (MDMA) causes apoptosis in nervous system and several studies suggest that oxidative stress contributes to MDMA-induced neurotoxicity. The aim of this study is to examine the effects of N-acetyl-L-Cystein (NAC) as an antioxidant on MDMA-induced apoptosis.
Methods: 21 Sprague dawley male rats (200-250mg) were treated with MDMA (2×0, 5mg/kg) or MDMA plus NAC (100mg/kg IP for 7 day). After last administration of MDMA, rats were killed, cerebellum was removed and Bax and Bcl-2 expression was assessed by western blotting method.
Results: The results of this study showed that MDMA causes up-regulation of Bax and down-regulation of Bcl-2 and NAC administration attenuated MDMA-induced apoptosis.
Discussion: The present study suggests that NAC treatment may improve MDMA-induced neurotoxicity.

 
Keyword(s): APOPTOSIS, N-METHYL-3, 4-METHYLENEDIOXYAMPHETAMINE, ACETYLCYSTEINE
 
 
References: 
  • Not Registered.
  •  
  •  
 
Citations: 
 
+ Click to Cite.
APA: Copy

SOLEIMANI ASL, S., & FALAHATI, P., & SHEKARRIZ, N., & MOLAVI, N., & ESMAEILI, F., & AZIMI, Z., & SAJADI, F., & HAYAT, P., & SAMZADEH KERMANI, A., & MEHDIZADEH, M. (2011). PROTECTIVE EFFECTS OF N-ACETYL-L-CYSTEIN ON 3, 4-METHYLENE DIOXYMETHAMPHETAMIE-INDUCED NEUROTOXICITY IN CEREBELLUM OF MALE RATS. BASIC AND CLINICAL NEUROSCIENCE, 3(1), 44-47. https://www.sid.ir/en/journal/ViewPaper.aspx?id=276290



Vancouver: Copy

SOLEIMANI ASL SARA, FALAHATI PEIMAN, SHEKARRIZ NIMA, MOLAVI NIMA, ESMAEILI FARZANEH, AZIMI ZAHRA, SAJADI FREIDOON, HAYAT PARISA, SAMZADEH KERMANI ALIREZA, MEHDIZADEH MEHDI. PROTECTIVE EFFECTS OF N-ACETYL-L-CYSTEIN ON 3, 4-METHYLENE DIOXYMETHAMPHETAMIE-INDUCED NEUROTOXICITY IN CEREBELLUM OF MALE RATS. BASIC AND CLINICAL NEUROSCIENCE. 2011 [cited 2021August01];3(1):44-47. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=276290



IEEE: Copy

SOLEIMANI ASL, S., FALAHATI, P., SHEKARRIZ, N., MOLAVI, N., ESMAEILI, F., AZIMI, Z., SAJADI, F., HAYAT, P., SAMZADEH KERMANI, A., MEHDIZADEH, M., 2011. PROTECTIVE EFFECTS OF N-ACETYL-L-CYSTEIN ON 3, 4-METHYLENE DIOXYMETHAMPHETAMIE-INDUCED NEUROTOXICITY IN CEREBELLUM OF MALE RATS. BASIC AND CLINICAL NEUROSCIENCE, [online] 3(1), pp.44-47. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=276290.



 
 
Yearly Visit 50
 
 
Latest on Blog
Enter SID Blog