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Paper Information

Journal:   BASIC AND CLINICAL NEUROSCIENCE   FALL 2011 , Volume 3 , Number 1; Page(s) 35 To 43.
 
Paper: 

CONTRIBUTION OF THE NUCLEUS CUNEIFORMIS TO THE ANTINOCICEPTIVE EFFECTS OF SYSTEMIC MORPHINE ON INFLAMMATORY PAIN IN RATS

 
 
Author(s):  RONAGHI ABDOLAZIZ, EBRAHIMZADEH MOHAMMAD, HAGHPARAST ABBAS*
 
* NEUROSCIENCE RESEARCH CENTER, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Introduction: The role of midbrain reticular formation, which includes the nucleus cuneiformis (NCF), as a crucial antinociceptive region in descending pain modulation has long been investigated. In this study, we tried to highlight the role of NCF in morphine-induced antinociception in formalin-induced pain model in rats.
Methods: A total of 201 male Wistar rats weighing 260-310 g were used in this study. The effective dose of morphine in systemic administration (intraperitoneal; i.p.) was determined after a dose- and time-response protocol. In consequent groups, bilateral electrolytic lesion (500
mA, 30 sec) or reversible inactivation (lidocaine 2%) were used in the NCF before systemic administration of morphine, and then, the nociceptive test was immediately carried out.
Results: The results showed that administration of 6 mg/kg morphine, 30 min before the formalin test, is the best dose- and time-response set in these experiments. The obtained data also indicated that bilateral electrical destruction or reversible inactivation of the NCF significantly decreased antinociceptive responses of systemic morphine (6 mg/kg; i.p.) during the second phase of formalin test (P<0.05).
Discussion: Therefore, it seems that opioid receptors located in the NCF may be involved in modulation of central sensitization which occurred in inflammatory pain in rats.

 
Keyword(s): NUCLEUS CUNEIFORMIS, ELECTROLYTIC LESION, REVERSIBLE INACTIVATION, MORPHINE, FORMALIN TEST, RAT
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

RONAGHI, A., & EBRAHIMZADEH, M., & HAGHPARAST, A. (2011). CONTRIBUTION OF THE NUCLEUS CUNEIFORMIS TO THE ANTINOCICEPTIVE EFFECTS OF SYSTEMIC MORPHINE ON INFLAMMATORY PAIN IN RATS. BASIC AND CLINICAL NEUROSCIENCE, 3(1), 35-43. https://www.sid.ir/en/journal/ViewPaper.aspx?id=276287



Vancouver: Copy

RONAGHI ABDOLAZIZ, EBRAHIMZADEH MOHAMMAD, HAGHPARAST ABBAS. CONTRIBUTION OF THE NUCLEUS CUNEIFORMIS TO THE ANTINOCICEPTIVE EFFECTS OF SYSTEMIC MORPHINE ON INFLAMMATORY PAIN IN RATS. BASIC AND CLINICAL NEUROSCIENCE. 2011 [cited 2021June13];3(1):35-43. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=276287



IEEE: Copy

RONAGHI, A., EBRAHIMZADEH, M., HAGHPARAST, A., 2011. CONTRIBUTION OF THE NUCLEUS CUNEIFORMIS TO THE ANTINOCICEPTIVE EFFECTS OF SYSTEMIC MORPHINE ON INFLAMMATORY PAIN IN RATS. BASIC AND CLINICAL NEUROSCIENCE, [online] 3(1), pp.35-43. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=276287.



 
 
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