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Paper Information

Journal:   BASIC AND CLINICAL NEUROSCIENCE   FALL 2011 , Volume 3 , Number 1; Page(s) 16 To 21.
 
Paper: 

THE EFFECTS OF BOSWELLIA RESIN EXTRACT ON DOPAMINERGIC CELL LINE, SK-N-SH, AGAINST MPP+-INDUCED NEUROTOXICITY

 
 
Author(s):  KAZMI SAREH, KAFAMI LAYA, EBRAHIMI AHMAD, JAMEIE BEHNAM, JOGHATAEI MOHAMMAD TAGHI*
 
* CELLULAR AND MOLECULAR RESEARCH CENTER, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, HEMMAT HIGHWAY, TEHRAN, IRAN
 
Abstract: 

Introduction: Oxidative stress and neuroinflammation are involved in neurodegeneration procedure in Parkinson’s disease. Recently, neuroprotective potential of Boswellia resin has been demonstrated. Therefore, this study examined whether administration of Boswellia resin would attenuate MPP+-induced neuronal death in SK-N-SH- cell line, a human dopaminergic neurons- in vitro.
Methods: Boswellia resin extract was added to culture medium (10
mg/ml) before and after exposure of SK-N-SH cell line to MPP+ (1000 mM). Cell viability and apoptosis features were assessed using MTT and Hoechst staining, respectively.
Results: Treatment with Boswellia resin 2 and 3h prior to MPP o exposure and up to 60 minutes after MPP o exposure significantly increased cell viability compare to untreated cells. Apoptotic features were also reduced significantly by Boswellia resin (10
mg/ml) compare to that of control untreated cells.
Discussion: Boswellia resin has neuroprotective effects on dopaminergic neurons which can be applicable in Parkinson’s disease.

 
Keyword(s): PARKINSON’S DISEASE, BOSWELLIA RESIN, SK-N-SH CELL LINE, MPP+
 
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