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Paper Information

Journal:   BASIC AND CLINICAL NEUROSCIENCE   SUMMER 2011 , Volume 2 , Number 4; Page(s) 58 To 66.
 
Paper: 

EFFECTS OF MINERALOCORTICOID RECEPTORS BLOCKADE ON FEAR MEMORY RECONSOLIDATION IN RATS

 
 
Author(s):  VAFAEI ABBAS ALI, PAKDEL ROGHYEH, NIKZAD SAEED, RASHIDY POUR ALI*
 
* LABORATORY OF LEARNING AND MEMORY, PHYSIOLOGICAL RESEARCH CENTER, SEMNAN UNIVERSITY OF MEDICAL SCIENCES, SEMNAN, IRAN
 
Abstract: 

Reconsolidation memory is defined as a process in which the retrieval of a previously consolidated memory returns to a labile state which is then subject to stabilization. Previous studies have shown that mineralocorticoid receptors (MRs) modulate distinct phases of learning and memory, which display a high concentration and distinct distribution in the hippocampus. Moreover, we found no studies that examined the role of hippocampal MRs in fear memory reconsolidation. Here, we investigated the effect of MRs blockade on fear memory reconsolidation in rats. Additionally, to test whether blockade of protein synthesis would disrupt fear memory reconsolidation in our paradigm, we tested the effect of cycloheximide, an inhibitor of protein synthesis after memory reactivation. Results indicated that systemic as well as intra-hippocampal administrations of the MR antagonist spironolactone immediately following memory reactivation did not affect on post-retrieval long-term memory. Cycloheximide given after the reactivation treatment produced a strong impairment that persisted over test sessions. These findings indicate that MRs are not required for reconsolidation of fear-based memory.

 
Keyword(s): MINERALOCORTICOID RECEPTOR, PASSIVE AVOIDANCE TASK, HIPPOCAMPUS, MEMORY RECONSOLIDATION, CYCLOHEXIMIDE, RAT
 
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